Analysis Tools
hematopoietic system
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• fewer Th17 T cells are derived from in vitro differentiation of nave CD4 T cells compared to controls under conditions of weak TCR signaling
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• splenocyte number is decreased by about 20%
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• mice generate less antigen-specific IgG2a to T cell-dependent antigens compared to controls
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immune system
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• fewer Th17 T cells are derived from in vitro differentiation of nave CD4 T cells compared to controls under conditions of weak TCR signaling
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• splenocyte number is decreased by about 20%
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• mice generate less antigen-specific IgG2a to T cell-dependent antigens compared to controls
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• splenocytes generate less IFN-gamma than controls after in vitro stimulation with antigen
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• CD4 T cells stimulated in vitro produce much less IL-17 than controls
• restimulated splenocytes isolated from mice with experimental autoimmune encephalomyelitis (EAE) produce less IL-17 than controls
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• CD4 T cells stimulated in vitro produce less IL-4 than controls
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• mice develop less severe EAE after MOG induction as measured by clinical score and weight loss
• less immune cells invade the spinal cord during the disease course of EAE compared to controls
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