Phenotypes associated with this allele

• Allele Symbol: Tg(Lck/Emu-Rftn1)1Ayos
• Allele Name: transgene insertion 1, Akihiko Yoshimura
• Allele ID: MGI:3850830
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Lck/Emu-Rftn1)1Ayos/?	involves: C57BL/6	MGI:3850843

Genotype
MGI:3850843

tg1

• Allelic Composition: Tg(Lck/Emu-Rftn1)1Ayos/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:150299 )

• T cell proliferation is slightly enhanced compared to controls

increased IgG1 level ( J:150299 )

• mice generate more antigen-specific IgG1 to T cell-dependent antigens 7 days after immunization compared to controls

increased IgG2a level ( J:150299 )

• mice generate more antigen-specific IgG2a to T cell-dependent antigens 7 days after immunization compared to controls

increased IgG3 level ( J:150299 )

• mice generate more antigen-specific IgG3 to T cell-dependent antigens 28 days after immunization compared to controls

increased IgM level ( J:150299 )

• mice generate more antigen-specific IgM to T cell-dependent antigens 28 days after immunization compared to controls

increased interferon-gamma secretion ( J:150299 )

• CD4 T cells stimulated in vitro produce more IFN-gamma than controls

increased interleukin-17 secretion ( J:150299 )

• CD4 T cells stimulated in vitro produce much more IL-17 than controls

increased interleukin-4 secretion ( J:150299 )

• CD4 T cells stimulated in vitro produce more IL-4 than controls

increased susceptibility to experimental autoimmune encephalomyelitis ( J:150299 )

• mice develop a more severe disease symptoms of EAE twelve days after MOG induction

• severe EAE symptoms last 21 days after disease induction when controls are recovering

• the number of immune cells invading the spinal cords is increased during the disease course of EAE compared to controls

hematopoietic system

increased T cell proliferation ( J:150299 )

• T cell proliferation is slightly enhanced compared to controls

increased IgG1 level ( J:150299 )

• mice generate more antigen-specific IgG1 to T cell-dependent antigens 7 days after immunization compared to controls

increased IgG2a level ( J:150299 )

• mice generate more antigen-specific IgG2a to T cell-dependent antigens 7 days after immunization compared to controls

increased IgG3 level ( J:150299 )

• mice generate more antigen-specific IgG3 to T cell-dependent antigens 28 days after immunization compared to controls

increased IgM level ( J:150299 )

• mice generate more antigen-specific IgM to T cell-dependent antigens 28 days after immunization compared to controls

cellular

increased T cell proliferation ( J:150299 )

• T cell proliferation is slightly enhanced compared to controls