Analysis Tools
neoplasm
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• at 8 months mice develop discolored reddish lesions mainly on the tail unlike wild-type mice
• mice develop Kaposi-like tumors with excessive proliferation of spindle cells without identifiable organized vascular structures inside the tumors but with slits containing red blood cells and hemosiderin between cells unlike in wild-type mice
• tumors prevalence is more severe in older, males homozygotes
• female mice develop Kaposi-like sarcomas later in life (mean age 18 months)
• tumors cells are positive for Kaposi sarcoma phenotypic markers CD31 and CD34
• tumor cells secrete more IL6, IL8, TNF-alpha, MCP1, MIP1alpha, and KC than in smooth muscle cells
• tumors exhibit increased reactive oxygen species-mediated oxidative DNA damage compared to in wild-type cells
• tumors cells exhibit polyploidy and aneuploidy
• tumors exhibit a two-fold increase in reactive oxygen species production compared with wild-type cells
• tumor cell growth is inhibited by N-acetyl-cysteine and stimulated by hydrogen peroxide
• however, treatment with N-acetyl-cysteine prevents limits the development of tumors
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immune system
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• tumor cells secrete more MCP1, MIP1alpha, and KC than in smooth muscle cells
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• in tumor cells compared with smooth muscle cells
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• in tumor cells compared with smooth muscle cells
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cellular
aneuploidy
(
J:150015
)
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• in tumor cells
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polyploidy
(
J:150015
)
|
• in tumor cells
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• tumors exhibit a two-fold increase in reactive oxygen species production compared with wild-type cells
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Kaposi's sarcoma | DOID:8632 | J:150015 | ||
