Phenotypes associated with this allele

• Allele Symbol: Git1^tm1.2Rtp
• Allele Name: targeted mutation 1.2, Richard T Premont
• Allele ID: MGI:3850987
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Git1^tm1.2Rtp/Git1^tm1.2Rtp	Not Specified	MGI:3850988

Genotype
MGI:3850988

hm1

• Allelic Composition: Git1^tm1.2Rtp/Git1^tm1.2Rtp
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:150460 )

• the number of mice surviving to adulthood is low compared to controls

behavior/neurological

impaired contextual conditioning behavior ( J:150460 )

• on day 3 of a cued fear conditioning test only a weak and transient response is seen in response to the conditioned stimulus

• no potentiation of the fear response is seen in response to a startle stimulus unlike in controls

• however, prior to training startle response is similar to controls

impaired cued conditioning behavior ( J:150460 )

• in a fear conditioning assay

decreased anxiety-related response ( J:150460 )

• reduced latencies to enter open areas or transition to any part of the maze in a zero maze assay

decreased fear-related response ( J:150460 )

• impairment of both cued and contextual fear conditioned responses

growth/size/body

decreased body weight ( J:150460 )

• slight decrease in body weight at weaning and as adults compared to wild-type controls