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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cul4atm1.1Pz
targeted mutation 1.1, Pengbo Zhou
MGI:3851024
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cul4atm1.1Pz/Cul4atm1.1Pz
Tg(KRT14-cre/ERT)20Efu/? 		involves: C57BL/6 * CD-1 MGI:3851141


Genotype
MGI:3851141
cn1
Allelic
Composition		 Cul4atm1.1Pz/Cul4atm1.1Pz
Tg(KRT14-cre/ERT)20Efu/?
Genetic
Background		 involves: C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4atm1.1Pz mutation (0 available); any Cul4a mutation (30 available)
Tg(KRT14-cre/ERT)20Efu mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by UV induction ( J:150427 )
• mice with cre induction in the skin are highly resistant to UVB induced tumors in the skin
• by 48 weeks of UVB treatmeant, all wild-type mice have developed squamous cell carcinomas while only 1 of 13 mutant mice have developed tumors




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory