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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cul4atm1.2Pz
targeted mutation 1.2, Pengbo Zhou
MGI:3851025
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cul4atm1.2Pz/Cul4atm1.2Pz B6.Cg-Cul4atm1.2Pz MGI:3851140


Genotype
MGI:3851140
hm1
Allelic
Composition
Cul4atm1.2Pz/Cul4atm1.2Pz
Genetic
Background
B6.Cg-Cul4atm1.2Pz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4atm1.2Pz mutation (0 available); any Cul4a mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in response to UV irradiation, embryonic fibroblasts (MEFs) spend 6 hours longer in the G1 phase before progressing into the S phase
• embryonic fibroblasts (MEFs) have about a 20% enhanced efficiency of the global genomic repair pathway
• MEFs spend 6 hours longer at the G1/S checkpoint after UV irradiation

homeostasis/metabolism
• embryonic fibroblasts (MEFs) have about a 20% enhanced efficiency of the global genomic repair pathway
• MEFs spend 6 hours longer at the G1/S checkpoint after UV irradiation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory