Phenotypes associated with this allele

• Allele Symbol: Myrf^tm1Barr
• Allele Name: targeted mutation 1, Ben Barres
• Allele ID: MGI:3851143
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Myrf^tm1Barr/Myrf^tm1Barr Cnp^tm1(cre)Kan/Cnp^+	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	MGI:3852096
cn2	Myrf^tm1Barr/Myrf^tm1Barr Olig2^tm2(TVA,cre)Rth/Olig2^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:3852094
cn3	Myrf^tm1Barr/Myrf^tm1Barr Tg(rx3-icre)1Mjam/0	involves: 129P2/OlaHsd * C57BL/6J	MGI:6383123
cn4	Myrf^tm1Barr/Myrf^+ Tg(rx3-icre)1Mjam/0	involves: 129P2/OlaHsd * C57BL/6J	MGI:6383124
cn5	Myrf^tm1Barr/Myrf^tm1.1Barr Tg(rx3-icre)1Mjam/0	involves: 129P2/OlaHsd * C57BL/6J	MGI:6383125

Genotype
MGI:3852096

cn1

• Allelic Composition: Myrf^tm1Barr/Myrf^tm1Barr; Cnp^tm1(cre)Kan/Cnp⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:150563 )

• mice die during third postnatal week

behavior/neurological

tremors ( J:150563 )

• severe tremors are observed

seizures ( J:150563 )

• seizures develop postnatally

nervous system

seizures ( J:150563 )

• seizures develop postnatally

abnormal oligodendrocyte morphology ( J:150563 )

• 2-fold higher levels of apoptotic cells (having blebbed processes, fragmented nuclei) are observed in premyelinating oligodendrocytes compared to controls; transition from premyelinating to mature oligodendrocytes is blocked when assayed at P7

• postmitotic oligodendrocytes are generated but then undergo apoptosis

abnormal spinal cord morphology ( J:150563 )

• severe loss of myelin is observed in spinal cord at P16, but spinal roots are myelinated

abnormal myelination ( J:150563 )

• severe loss of myelination in CNS white matter tracts is observed at P16

Genotype
MGI:3852094

cn2

• Allelic Composition: Myrf^tm1Barr/Myrf^tm1Barr; Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

mortality/aging

postnatal lethality, complete penetrance ( J:150563 )

• mice die during third postnatal week

behavior/neurological

tremors ( J:150563 )

• severe tremors are observed around P11

ataxia ( J:150563 )

• observed around P11

seizures ( J:150563 )

• develop after P10

nervous system

nervous system phenotype ( J:150563 )

N • gross CNS architecture is normal

N • motor neuron population in spinal cord is intact

N • peripheral nerves are fully myelinated

seizures ( J:150563 )

• develop after P10

abnormal optic nerve morphology ( J:150563 )

• at P13, optic nerve axons show almost no myelination in contrast to wild-type controls where about 50% of axons are myelinated

abnormal spinal cord morphology ( J:150563 )

• severe loss of myelin basic protein (immunostaining) is observed in spinal cord at P13, but spinal root myelination (myelinated by Schwann cells) is normal

abnormal myelination ( J:150563 )

• essentially complete loss of myelination in CNS white matter tracts is observed at P13

vision/eye

abnormal optic nerve morphology ( J:150563 )

• at P13, optic nerve axons show almost no myelination in contrast to wild-type controls where about 50% of axons are myelinated

Genotype
MGI:6383123

cn3

• Allelic Composition: Myrf^tm1Barr/Myrf^tm1Barr; Tg(rx3-icre)1Mjam/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

vision/eye

decreased retina cone cell number ( J:275842 )

short photoreceptor inner segment ( J:275842 )

• by P22, especially overlying depigmented areas

short photoreceptor outer segment ( J:275842 )

• especially overlying depigmented areas

abnormal retina pigmentation ( J:275842 )

• patchy loss of pigmentation as early as E15.5

retina pigment epithelium atrophy ( J:275842 )

thin retina outer nuclear layer ( J:275842 )

• especially overlying depigmented areas

decreased total retina thickness ( J:275842 )

retina degeneration ( J:275842 )

abnormal cone electrophysiology ( J:275842 )

• reduced peak flicker amplitude

abnormal rod electrophysiology ( J:275842 )

• reduced a- and b-wave amplitudes

nervous system

decreased retina cone cell number ( J:275842 )

short photoreceptor inner segment ( J:275842 )

• by P22, especially overlying depigmented areas

short photoreceptor outer segment ( J:275842 )

• especially overlying depigmented areas

pigmentation

abnormal retina pigmentation ( J:275842 )

• patchy loss of pigmentation as early as E15.5

retina pigment epithelium atrophy ( J:275842 )

Genotype
MGI:6383124

cn4

• Allelic Composition: Myrf^tm1Barr/Myrf⁺; Tg(rx3-icre)1Mjam/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

vision/eye

retina pigment epithelium atrophy ( J:275842 )

retina degeneration ( J:275842 )

• late onset; less severe than in mice homozygous for the conditional allele

pigmentation

retina pigment epithelium atrophy ( J:275842 )

Genotype
MGI:6383125

cn5

• Allelic Composition: Myrf^tm1Barr/Myrf^tm1.1Barr; Tg(rx3-icre)1Mjam/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

pigmentation

abnormal retina pigmentation ( J:275842 )

• patchy loss of pigmentation

vision/eye

abnormal retina pigmentation ( J:275842 )

• patchy loss of pigmentation