Phenotypes associated with this allele

• Allele Symbol: Cplx4^tm1Bros
• Allele Name: targeted mutation 1, Nils Brose
• Allele ID: MGI:3851151
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cplx4^tm1Bros/Cplx4^tm1Bros	involves: C57BL/6	MGI:3851182
cx2	Cplx3^tm1Bros/Cplx3^tm1Bros Cplx4^tm1Bros/Cplx4^tm1Bros	involves: C57BL/6	MGI:3851183

Genotype
MGI:3851182

hm1

• Allelic Composition: Cplx4^tm1Bros/Cplx4^tm1Bros
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:150490 )

N • despite eye electrophysiological abnormalities, no defects in retinal morphology are detected

abnormal eye electrophysiology ( J:150490 )

• slight but significant reduction in a-wave amplitude at medium light intensities

• slight increase in peak frequency of oscillatory potentials

abnormal rod electrophysiology ( J:150490 )

• slight but significant reduction in b-wave amplitude at the lowest light intensities tested

Genotype
MGI:3851183

cx2

• Allelic Composition: Cplx3^tm1Bros/Cplx3^tm1Bros; Cplx4^tm1Bros/Cplx4^tm1Bros
• Genetic Background: involves: C57BL/6

vision/eye

abnormal retina photoreceptor morphology ( J:150490 )

• many photoreceptor ribbon synapse complexes are disintegrated

• in adults photoreceptor terminals containing spherical free floating ribbons are seen

disorganized retina outer plexiform layer ( J:150490 )

abnormal eye electrophysiology ( J:150490 )

• significant reduction in b-wave amplitudes and prolongation of b-wave implicit times at all light intensities

• slight increase in a-wave amplitudes and prolongation of a-wave implicit times at medium light intensities

• peak power but not peak frequency of oscillatory potentials is reduced

abnormal vision ( J:150490 )

• mice take more time to reach the visible platform in a cued platform test in the Morris water maze; however, mice show a normal learning curve in this test and normal motor function indicating the delay is due to impaired vision

• in contrast, performance in a visual cliff test is similar to controls

nervous system

abnormal retina photoreceptor morphology ( J:150490 )

• many photoreceptor ribbon synapse complexes are disintegrated

• in adults photoreceptor terminals containing spherical free floating ribbons are seen