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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aifm1tm2.1Pngr
targeted mutation 2.1, Josef M Penninger
MGI:3851178
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aifm1tm2.1Pngr/Aifm1tm2.1Pngr involves: 129P2/OlaHsd * FVB/N MGI:3851181
ht2
 		Aifm1tm2.1Pngr/Aifm1+ involves: 129P2/OlaHsd * FVB/N MGI:3851179
ot3
 		Aifm1tm2.1Pngr/Y involves: 129P2/OlaHsd * FVB/N MGI:3851180


Genotype
MGI:3851181
hm1
Allelic
Composition		 Aifm1tm2.1Pngr/Aifm1tm2.1Pngr
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aifm1tm2.1Pngr mutation (0 available); any Aifm1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
increased embryonic tissue cell apoptosis ( J:111066 )
• at E9 (20 to 25 somite stage), embryos exhibit increased apoptosis compared with wild-type mice
decreased embryo size ( J:111066 )
• at E9 (20 to 21 somite stage), mice are smaller than normal due to fewer cells
decreased somite size ( J:111066 )
• slightly reduced size at E9

cellular
increased embryonic tissue cell apoptosis ( J:111066 )
• at E9 (20 to 25 somite stage), embryos exhibit increased apoptosis compared with wild-type mice
abnormal respiratory electron transport chain ( J:111066 )
• at 7 to 13 somite stages, mitochondria RC complex I activity is impaired

growth/size/body
decreased embryo size ( J:111066 )
• at E9 (20 to 21 somite stage), mice are smaller than normal due to fewer cells

nervous system
decreased brain size ( J:111066 )
• slightly reduced anterior brain at E9




Genotype
MGI:3851179
ht2
Allelic
Composition		 Aifm1tm2.1Pngr/Aifm1+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aifm1tm2.1Pngr mutation (0 available); any Aifm1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, incomplete penetrance ( J:111066 )
• most mice die during embryogenesis




Genotype
MGI:3851180
ot3
Allelic
Composition		 Aifm1tm2.1Pngr/Y
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aifm1tm2.1Pngr mutation (0 available); any Aifm1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
increased embryonic tissue cell apoptosis ( J:111066 )
• at E9 (20 to 25 somite stage), embryos exhibit increased apoptosis compared with wild-type mice
decreased embryo size ( J:111066 )
• at E9 (20 to 21 somite stage), mice are smaller than normal due to fewer cells
decreased somite size ( J:111066 )
• slightly reduced size at E9

cellular
increased embryonic tissue cell apoptosis ( J:111066 )
• at E9 (20 to 25 somite stage), embryos exhibit increased apoptosis compared with wild-type mice
abnormal respiratory electron transport chain ( J:111066 )
• at 7 to 13 somite stages, mitochondria RC complex I activity is impaired

growth/size/body
decreased embryo size ( J:111066 )
• at E9 (20 to 21 somite stage), mice are smaller than normal due to fewer cells

nervous system
decreased brain size ( J:111066 )
• slightly reduced anterior brain at E9




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory