All Phenotypes Tg(Cd8a-cre)1Itan MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd8a-cre)1Itan/0	B6(129S4)-Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd8a-cre)1Itan	MGI:7657890
cn2	Zbtb7b^tm6.1Itan/Zbtb7b^tm6.1Itan Tg(Cd8a-cre)1Itan/?	involves: C57BL/6	MGI:5506931
cn3	Pik3c3^tm1.1Flv/Pik3c3^tm1.1Flv Tg(Cd8a-cre)1Itan/0	involves: C57BL/6 * C57BL/6N	MGI:5427890
cn4	Notch2^tm1.1Hhi/Notch2^tm1.1Hhi Tg(Cd8a-cre)1Itan/0	involves: C57BL/6 * CBA	MGI:3851205

Allelic Composition	Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd8a-cre)1Itan/0
Genetic Background	B6(129S4)-Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd8a-cre)1Itan

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctps1^{tm1c(KOMP)Wtsi} mutation (0 available); any Ctps1 mutation (46 available)
Tg(Cd8a-cre)1Itan mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell proliferation ( J:348981 )

• upon activation with anti-CD3/CD28, CD8+ T cells from the spleen fail to proliferate leading to an effector memory CD8+ T cell impairment

• addition of cytidine to the culture medium during the activation rescues the proliferation defect of the CD8+ T cells

• however, no phenotypic differences are seen in the thymus and spleen, and no abnormalities are detected in blood, spleen cellularity and cell type composition

immune system

decreased T cell proliferation ( J:348981 )

• upon activation with anti-CD3/CD28, CD8+ T cells from the spleen fail to proliferate leading to an effector memory CD8+ T cell impairment

• addition of cytidine to the culture medium during the activation rescues the proliferation defect of the CD8+ T cells

• however, no phenotypic differences are seen in the thymus and spleen, and no abnormalities are detected in blood, spleen cellularity and cell type composition

cellular

decreased T cell proliferation ( J:348981 )

• upon activation with anti-CD3/CD28, CD8+ T cells from the spleen fail to proliferate leading to an effector memory CD8+ T cell impairment

• addition of cytidine to the culture medium during the activation rescues the proliferation defect of the CD8+ T cells

• however, no phenotypic differences are seen in the thymus and spleen, and no abnormalities are detected in blood, spleen cellularity and cell type composition

Allelic Composition	Zbtb7b^tm6.1Itan/Zbtb7b^tm6.1Itan Tg(Cd8a-cre)1Itan/?
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd8a-cre)1Itan mutation (1 available)
Zbtb7b^tm6.1Itan mutation (0 available); any Zbtb7b mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:195348 )

N	• CD8+ T cell development is normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:184753 )

N	• T cell development is normal

increased T cell apoptosis ( J:184753 )

• CD8+ T cells exhibit increased spontaneous apoptosis ex vivo compared with wild-type cells

decreased lymphocyte cell number ( J:184753 )

• T cell lymphopenia is cell autonomous based on bone marrow chimera experiments

abnormal CD4-positive, alpha beta T cell morphology ( J:184753 )

• CD4+ T cells exhibit increased mitochondrial mass compared with control cells

• CD4+ and CD8+ T cells exhibit increased reactive oxygen species compared with control cells

decreased CD4-positive, alpha-beta T cell number ( J:184753 )

• in lymph node

abnormal CD8-positive, alpha beta T cell morphology ( J:184753 )

• CD8+ T cells exhibit increased mitochondrial mass compared with control cells

• CD4+ and CD8+ T cells exhibit increased reactive oxygen species compared with control cells

decreased CD8-positive, alpha-beta T cell number ( J:184753 )

• in spleen and lymph node

cellular

abnormal mitochondrial morphology ( J:184753 )

• CD8+ and to a lesser extent CD4+ T cells exhibit increased mitochondrial mass compared with control cells

increased T cell apoptosis ( J:184753 )

• CD8+ T cells exhibit increased spontaneous apoptosis ex vivo compared with wild-type cells

abnormal mitochondrial physiology ( J:184753 )

• mitophagy is reduced in CD8+ and CD4+ T cells

oxidative stress ( J:184753 )

• CD4+ and CD8+ T cells exhibit increased reactive oxygen species compared with control cells

hematopoietic system

increased T cell apoptosis ( J:184753 )

• CD8+ T cells exhibit increased spontaneous apoptosis ex vivo compared with wild-type cells

decreased lymphocyte cell number ( J:184753 )

• T cell lymphopenia is cell autonomous based on bone marrow chimera experiments

abnormal CD4-positive, alpha beta T cell morphology ( J:184753 )

• CD4+ T cells exhibit increased mitochondrial mass compared with control cells

• CD4+ and CD8+ T cells exhibit increased reactive oxygen species compared with control cells

decreased CD4-positive, alpha-beta T cell number ( J:184753 )

• in lymph node

abnormal CD8-positive, alpha beta T cell morphology ( J:184753 )

• CD8+ T cells exhibit increased mitochondrial mass compared with control cells

• CD4+ and CD8+ T cells exhibit increased reactive oxygen species compared with control cells

decreased CD8-positive, alpha-beta T cell number ( J:184753 )

• in spleen and lymph node

Allelic Composition	Notch2^tm1.1Hhi/Notch2^tm1.1Hhi Tg(Cd8a-cre)1Itan/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2^tm1.1Hhi mutation (1 available); any Notch2 mutation (97 available)
Tg(Cd8a-cre)1Itan mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell physiology ( J:141009 )

• cells produce less granzyme B than control cells after stimulation with allogeneic control dendritic cells (DCs) or DL1-DCs

abnormal cytotoxic T cell physiology ( J:141009 )

• mice, injected with spleen cells that were pulsed with OT-I (ova) peptide and 4 days later given labeled spleen cells or labeled spleen cells that were pulsed with OT-I (ova) peptide show little CTL-mediated killing of either population; in contrast, control mice display preferential cytolysis of OT-I pulsed spleen cells

increased susceptibility to parasitic infection ( J:141009 )

• mice display much earlier death after Trypanosoma cruzi infection compared to controls

hematopoietic system

abnormal CD8-positive, alpha-beta T cell physiology ( J:141009 )

• cells produce less granzyme B than control cells after stimulation with allogeneic control dendritic cells (DCs) or DL1-DCs

abnormal cytotoxic T cell physiology ( J:141009 )

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