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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Muc2M1Btlr
mutation 1, Bruce Beutler
MGI:3851216
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Muc2M1Btlr/Muc2M1Btlr C57BL/6J-Muc2M1Btlr MGI:3851217
ht2
 		Muc2M1Btlr/Muc2+ C57BL/6J-Muc2M1Btlr MGI:3851218


Genotype
MGI:3851217
hm1
Allelic
Composition		 Muc2M1Btlr/Muc2M1Btlr
Genetic
Background		 C57BL/6J-Muc2M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Muc2M1Btlr mutation (1 available); any Muc2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased susceptibility to induced colitis ( J:150326 )
• by five days after initiation of treatment with a low dose (1%) of dextran sulfate sodium (DSS) in their drinking water, mice homozygous for this mutation exhibit greater weight loss than do wild-type control mice; after this time point the weight of mutant mice continues to decline, whereas that of wild-type animals appears to stabilize

immune system
increased susceptibility to induced colitis ( J:150326 )
• by five days after initiation of treatment with a low dose (1%) of dextran sulfate sodium (DSS) in their drinking water, mice homozygous for this mutation exhibit greater weight loss than do wild-type control mice; after this time point the weight of mutant mice continues to decline, whereas that of wild-type animals appears to stabilize




Genotype
MGI:3851218
ht2
Allelic
Composition		 Muc2M1Btlr/Muc2+
Genetic
Background		 C57BL/6J-Muc2M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Muc2M1Btlr mutation (1 available); any Muc2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased susceptibility to induced colitis ( J:150326 )
• from five days after initiation of treatment with a low dose (1%) of dextran sulfate sodium (DSS) in their drinking water, mice heterozygous for this mutation exhibit weight loss intermediate between that of homozygous mutant and wild-type mice

immune system
increased susceptibility to induced colitis ( J:150326 )
• from five days after initiation of treatment with a low dose (1%) of dextran sulfate sodium (DSS) in their drinking water, mice heterozygous for this mutation exhibit weight loss intermediate between that of homozygous mutant and wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory