Phenotypes associated with this allele

• Allele Symbol: Tph2^tm1.2Kpl
• Allele Name: targeted mutation 1.2, Klaus-Peter Lesch
• Allele ID: MGI:3851254
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tph2^tm1.2Kpl/Tph2^tm1.2Kpl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3851261

Genotype
MGI:3851261

hm1

• Allelic Composition: Tph2^tm1.2Kpl/Tph2^tm1.2Kpl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:150637 )

N • mice exhibit normal life spans

nervous system

nervous system phenotype ( J:150637 )

N • mice have normal overall brain structure

abnormal serotonergic neuron morphology ( J:150637 )

• serotonin-expressing neurons are absent from the raphe nuclei unlike in wild-type mice

• however, serotonin neurons are detected in the pineal gland