immune system
• culturing CD4+ T cells under Th17-polarizing conditions produces very few Th17 T cells
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• CD8+ T cells and lamina propia T cells fail to produce IL-17
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• CD4+ T cells cultured under Th17-polarizing conditions fail to produce IL-21
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• mice are completely resistant to EAE induced by MOG-peptide immunization
• T cells infiltrating the spinal cord of mice do not produce IL-17 after EAE induction in the manner that wild-type mice do
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hematopoietic system
• culturing CD4+ T cells under Th17-polarizing conditions produces very few Th17 T cells
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