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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mt1-CBS*S466L)EB86Waku
transgene insertion EB86, Warren Kruger
MGI:3851386
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cbstm1Unc/Cbstm1Unc
Tg(Mt1-CBS*S466L)EB86Waku/0 		involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:3851395


Genotype
MGI:3851395
cx1
Allelic
Composition		 Cbstm1Unc/Cbstm1Unc
Tg(Mt1-CBS*S466L)EB86Waku/0
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbstm1Unc mutation (3 available); any Cbs mutation (43 available)
Tg(Mt1-CBS*S466L)EB86Waku mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased monocyte cell number ( J:168131 )
• increase in monocyte population in blood, spleen, and bone marrow of 6 month old zinc-induced mice with severe hyperhomocysteinemia which is further increased at 8 months of age
increased Ly6C high monocyte number ( J:168131 )
• zinc-induced mice with severe hyperhomocysteinemia exhibit elevated CD11b+Ly-6Chi and CD11b+Ly-6Cmid inflammatory monocyte subsets

homeostasis/metabolism
increased circulating homocysteine level ( J:150548 , J:168131 )
• plasma N-homocysteine levels in zinc-induced mice are 6.4-fold to 12.8-fold higher than in Cbstm1Unc Tg(Mt1-CBS*S466L)EB86Waku heterozygotes or Tg(Mt1-CBS*S466L)EB86Waku mice (J:150548)
• total plasma homocysteine levels in zinc-induced mice are higher than in Cbstm1Unc Tg(Mt1-CBS*S466L)EB86Waku heterozygotes or Tg(Mt1-CBS*S466L)EB86Waku mice (J:150548)
• plasma homocysteine is greatly increased in 6 month old zinc-induced mice, with no further change at 8 months (J:168131)
increased circulating methionine level ( J:168131 )
• plasma methionine levels are slightly elevated and slightly increase with age in zinc-induced mice

immune system
increased monocyte cell number ( J:168131 )
• increase in monocyte population in blood, spleen, and bone marrow of 6 month old zinc-induced mice with severe hyperhomocysteinemia which is further increased at 8 months of age
increased Ly6C high monocyte number ( J:168131 )
• zinc-induced mice with severe hyperhomocysteinemia exhibit elevated CD11b+Ly-6Chi and CD11b+Ly-6Cmid inflammatory monocyte subsets




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory