Phenotypes associated with this allele

• Allele Symbol: Tg(Mt1-CBS*I278T)1Waku
• Allele Name: transgene insertion 1, Warren Kruger
• Allele ID: MGI:3851388
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cbs^tm1Unc/Cbs^tm1Unc Tg(Mt1-CBS*I278T)1Waku/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:3851396

Genotype
MGI:3851396

cx1

• Allelic Composition: Cbs^tm1Unc/Cbs^tm1Unc; Tg(Mt1-CBS*I278T)1Waku/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal amino acid level ( J:150548 )

• liver N-homocysteine levels in zinc-induced mice are 11.5-fold higher than in Cbs^tm1Unc Tg(Mt1-CBS* I278T)1Waku heterozygotes or Tg(Mt1-CBS* I278T)1Waku mice

• total liver homocysteine levels in zinc-induced mice are 51- to 75-fold higher than in Cbs^tm1Unc Tg(Mt1-CBS* I278T)1Waku heterozygotes or Tg(Mt1-CBS* I278T)1Waku mice

• N-homocysteine levels in zinc-induced mice are 3.3-fold greater than in Cbs^tm1Unc/Cbs^tm1Unc Tg(Mt1-CBS)25Waku mice

abnormal circulating homocysteine level ( J:150548 )

• plasma N-homocysteine levels in zinc-induced mice are 6.3-fold to 10.6-fold higher than in Cbs^tm1Unc Tg(Mt1-CBS* I278T)1Waku heterozygotes or Tg(Mt1-CBS* I278T)1Waku mice

• total plasma homocysteine levels in zinc-induced mice are 54- to 143-fold higher than in Cbs^tm1Unc Tg(Mt1-CBS* I278T)1Waku heterozygotes or Tg(Mt1-CBS* I278T)1Waku mice