Phenotypes associated with this allele

• Allele Symbol: Pde4a^tm1.1Hazh
• Allele Name: targeted mutation 1.1, Haiqing Zhao
• Allele ID: MGI:3851439
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pde4a^tm1.1Hazh/Pde4a^tm1.1Hazh	involves: 129S6/SvEvTac	MGI:3851454
cx2	Pde1c^tm1.1Hazh/Pde1c^tm1.1Hazh Pde4a^tm1.1Hazh/Pde4a^tm1.1Hazh	involves: 129S6/SvEvTac	MGI:3851453

Genotype
MGI:3851454

hm1

• Allelic Composition: Pde4a^tm1.1Hazh/Pde4a^tm1.1Hazh
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:150514 )

N • no abnormalities in olfactory sensory nerve transduction are detected

Genotype
MGI:3851453

cx2

• Allelic Composition: Pde1c^tm1.1Hazh/Pde1c^tm1.1Hazh; Pde4a^tm1.1Hazh/Pde4a^tm1.1Hazh
• Genetic Background: involves: 129S6/SvEvTac

taste/olfaction

abnormal olfactory system physiology ( J:150514 )

• olfacotory sensory nerves (OSN) that fire in response to amyl acetate and heptaldehyde have prolonged response termination of their action potentials compared to controls

• OSN also have significantly reduced amplitudes with slower onset kinetics

• amplitude is about half that of controls

• increase in the response rise time is greater than that for Pde1c^tm1.1Hazh homozygotes

• OSN have a "noiser" action potential background level

abnormal odor adaptation ( J:150514 )

• mice have attenuated odor adaptation to a 10 second sustained odor stimulus that is about half that of controls

• unlike Pde1c^tm1.1Hazh homozygotes, these double knockouts do not have abnormal odor adaption to short pulses of odor