Analysis Tools
mortality/aging
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• some mice die between 8 to 10 months due to injuries sustain from fighting with other mice
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• however, treatment of pregnant dams with doxycycline eliminates prenatal lethality
• fewer than expected mice are recovered due to prenatal lethality
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nervous system
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• ventricles are enlarged compared to in wild-type mice
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• the area of the caudate putamen is reduced compared to in wild-type mice
• however, treatment with doxycycline after the onset of symptoms restores some of the caudate putamen area
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• the striatum is reduced in size compared to in wild-type mice
• the ventricular zone of the striatum is narrower than in wild-type mice
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astrocytosis
(
J:61490
)
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• mice exhibit reactive astrocytosis in the striatum that spreads over time
• however, treatment with doxycycline after the onset of symptoms reduces astrocytosis
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• mice develop neuronal intranuclear and extranuclear inclusion
• however, treatment with doxycycline after the onset of symptoms alleviates inclusions
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behavior/neurological
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• in older mice with tremors
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limb grasping
(
J:61490
)
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• beginning at 4 weeks, some mice exhibit limb grasping when suspended
• by 8 weeks, all mice display clasping that can last after mice are released
• however, treatment with doxycycline after the onset of symptoms reduces glasping behavior and duration
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• mice exhibit progressive motor dysfunction with choreic and dystonic movements, and parkinsonism
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• mild tremors begin at 20 weeks in some mice
• in some mice tremors develop into a jerking motion
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• at 36 weeks
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muscle
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• mice exhibit progressive motor dysfunction with choreic and dystonic movements, and parkinsonism
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Huntington's disease | DOID:12858 |
OMIM:143100 |
J:61490 | |
