Analysis Tools
respiratory system
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• after 3 months of age, parenchyma shows large eosinophilic macrophage infiltration
• between 5 and 10 months, mice have focal accumulation and infiltration of mononuclear cells including nodular collections of mononuclear CD4 lymphocytes
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• at 3 months of age, epithelium is hypertrophic in bronchus and bronchioles
• mucous production by airway epithelium is increased compared to controls
• subepithelium of bronchioles has substantial deposits of collagen in contrast to controls
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• alveolar walls are thickened compared to controls
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• in 5 month-old mice, bronchioles contain long thin neendle-like crystals
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immune system
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• chemokines including CCL7, CCL10, CCL20, CCL11 and CXCL1 show increased expression in lungs of transgenics; TIMP-1 and MMP-9 levels in lungs are elevated
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• after 3 months of age, parenchyma shows large eosinophilic macrophage infiltration
• between 5 and 10 months, mice have focal accumulation and infiltration of mononuclear cells including nodular collections of mononuclear CD4 lymphocytes
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homeostasis/metabolism
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• chemokines including CCL7, CCL10, CCL20, CCL11 and CXCL1 show increased expression in lungs of transgenics; TIMP-1 and MMP-9 levels in lungs are elevated
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