All Phenotypes Efnb3<tm2.1Henk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Efnb3^tm2.1Henk
targeted mutation 2.1, Mark Henkemeyer
MGI:3851474

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Efnb3^tm2.1Henk/Efnb3^tm2.1Henk	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851494

Allelic Composition	Efnb3^tm2.1Henk/Efnb3^tm2.1Henk
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb3^tm2.1Henk mutation (0 available); any Efnb3 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

• dentate granule cells cocultured with Cos-1 cells exhibit longer neurites than similarly treated wild-type cells due to defective pruning

abnormal axon morphology ( J:150550 )

• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

cellular

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

• dentate granule cells cocultured with Cos-1 cells exhibit longer neurites than similarly treated wild-type cells due to defective pruning

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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