Analysis Tools
cardiovascular system
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• similar increase in myocyte cross-sectional area in left ventricle is observed in induced transgenic mice and controls after angiotensin II and isoproterenol infusion
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• induced (removal of doxycycline treatment) mice show the same hypertrophic response to procedures such as transverse aortic constriction (TAC) and forced exercise as wild-type and single transgenic controls
• hypertrophy in response to agonists such as angiotensin II and isoproterenol is identical to that seen in treated wild-type after 14 days
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• after 14 days of isoproterenol infusion, mice display 2-fold greater fibrosis than control mice
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• medium- and high-expressing transgenic mice show significantly greater decompensation after 14 weeks of transverse aortic constriction compared to wild-type
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muscle
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• similar increase in myocyte cross-sectional area in left ventricle is observed in induced transgenic mice and controls after angiotensin II and isoproterenol infusion
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• medium- and high-expressing transgenic mice show significantly greater decompensation after 14 weeks of transverse aortic constriction compared to wild-type
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• 1 week of acute pressure overload caused increased TUNEL rates in high- and medium-expressing mice and remain elevated after 14 weeks of TAC in high-expressing mice
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respiratory system
cellular
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• 1 week of acute pressure overload caused increased TUNEL rates in high- and medium-expressing mice and remain elevated after 14 weeks of TAC in high-expressing mice
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growth/size/body
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• induced (removal of doxycycline treatment) mice show the same hypertrophic response to procedures such as transverse aortic constriction (TAC) and forced exercise as wild-type and single transgenic controls
• hypertrophy in response to agonists such as angiotensin II and isoproterenol is identical to that seen in treated wild-type after 14 days
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