cardiovascular system
• induced mice show equivalent infarcted area/area at risk ratio to wild-type after myocardial infarction
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• by 16 weeks after MI, wild-type mice show significant increases in heart weight/body weight ratios, but induced mutants exhibit partial protection from changes
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• induced mice show greater fractional shortening (%) than wild-type up to 3 weeks after myocardial infarction (MI)
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• induced adult mice (no doxycycline) showed increased contractility at baseline and with dobutamine infusion compared with wild-type mice; mutant mice treated with doxycycline show no increased contractility compared to wild-type
• by 12 and 16 weeks after MI, induced mice show reduced ventricular performance similar to wild-type with MI
• induced mice show greater fractional shortening (%) than wild-type up to 3 weeks after myocardial infarction (MI)
• after experimental myocardial infarction (MI), uninduced mice (doxycycline treated) showed decreased ventricular function whereas mice without doxycycline (induced) show partial protection against functional performance deficits at 1 and 2 weeks following MI
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muscle
• induced mice show equivalent infarcted area/area at risk ratio to wild-type after myocardial infarction
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• induced mice show greater fractional shortening (%) than wild-type up to 3 weeks after myocardial infarction (MI)
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• induced adult mice (no doxycycline) showed increased contractility at baseline and with dobutamine infusion compared with wild-type mice; mutant mice treated with doxycycline show no increased contractility compared to wild-type
• by 12 and 16 weeks after MI, induced mice show reduced ventricular performance similar to wild-type with MI
• induced mice show greater fractional shortening (%) than wild-type up to 3 weeks after myocardial infarction (MI)
• after experimental myocardial infarction (MI), uninduced mice (doxycycline treated) showed decreased ventricular function whereas mice without doxycycline (induced) show partial protection against functional performance deficits at 1 and 2 weeks following MI
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growth/size/body
• by 16 weeks after MI, wild-type mice show significant increases in heart weight/body weight ratios, but induced mutants exhibit partial protection from changes
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