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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6/tetO-PRKCA*)1Jmk
transgene insertion 1, Jeffery D Molkentin
MGI:3851565
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Myh6-tTA)55Rbns/0
Tg(Myh6/tetO-PRKCA*)1Jmk/0
involves: FVB/N MGI:3851897


Genotype
MGI:3851897
cx1
Allelic
Composition
Tg(Myh6-tTA)55Rbns/0
Tg(Myh6/tetO-PRKCA*)1Jmk/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6/tetO-PRKCA*)1Jmk mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• induced mice show equivalent infarcted area/area at risk ratio to wild-type after myocardial infarction
• by 16 weeks after MI, wild-type mice show significant increases in heart weight/body weight ratios, but induced mutants exhibit partial protection from changes
• induced mice show greater fractional shortening (%) than wild-type up to 3 weeks after myocardial infarction (MI)
• induced adult mice (no doxycycline) showed increased contractility at baseline and with dobutamine infusion compared with wild-type mice; mutant mice treated with doxycycline show no increased contractility compared to wild-type
• by 12 and 16 weeks after MI, induced mice show reduced ventricular performance similar to wild-type with MI
• induced mice show greater fractional shortening (%) than wild-type up to 3 weeks after myocardial infarction (MI)
• after experimental myocardial infarction (MI), uninduced mice (doxycycline treated) showed decreased ventricular function whereas mice without doxycycline (induced) show partial protection against functional performance deficits at 1 and 2 weeks following MI

muscle
• induced mice show equivalent infarcted area/area at risk ratio to wild-type after myocardial infarction
• induced mice show greater fractional shortening (%) than wild-type up to 3 weeks after myocardial infarction (MI)
• induced adult mice (no doxycycline) showed increased contractility at baseline and with dobutamine infusion compared with wild-type mice; mutant mice treated with doxycycline show no increased contractility compared to wild-type
• by 12 and 16 weeks after MI, induced mice show reduced ventricular performance similar to wild-type with MI
• induced mice show greater fractional shortening (%) than wild-type up to 3 weeks after myocardial infarction (MI)
• after experimental myocardial infarction (MI), uninduced mice (doxycycline treated) showed decreased ventricular function whereas mice without doxycycline (induced) show partial protection against functional performance deficits at 1 and 2 weeks following MI

growth/size/body
• by 16 weeks after MI, wild-type mice show significant increases in heart weight/body weight ratios, but induced mutants exhibit partial protection from changes





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory