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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Mapk14*)1Jmol
transgene insertion 1, Jeffery D Molkentin
MGI:3851575
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Tg(Myh6-Mapk14*)1Jmol/0
involves: 129S6/SvEvTac * C57BL/6 * FVB MGI:3851717
tg2
Tg(Myh6-Mapk14*)1Jmol/0 FVB-Tg(Myh6-Mapk14*)1Jmol MGI:3851716


Genotype
MGI:3851717
cx1
Allelic
Composition
Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Tg(Myh6-Mapk14*)1Jmol/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cbtm1Jmk mutation (1 available); any Ppp3cb mutation (67 available)
Tg(Myh6-Mapk14*)1Jmol mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• at 2 months, mice show complete rescue in hypertrophic growth seen in Tg(Myh6-Mapk14*)1Jmol animals
• rescue of the chamber enlargement and reduced fractional shortening is also observed
• interstitial cell fibrosis is significantly attenuated compare with Tg(Myh6-Mapk14*)1Jmol mice




Genotype
MGI:3851716
tg2
Allelic
Composition
Tg(Myh6-Mapk14*)1Jmol/0
Genetic
Background
FVB-Tg(Myh6-Mapk14*)1Jmol
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Mapk14*)1Jmol mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die by 8 months from lethal cardiomyopathy

cardiovascular system
• myocyte cross-sectional area is increased significantly by 4 months of age
• at 2 months, mice show significant increase in heart-to-body weight ratios that increase with age compared to controls
• before 2 months of age, mice exhibit concentric hypertrophic remodeling
• end-diastolic and end-systolic dimensions are significantly increased, with unchanged or decreased wall thicknesses suggesting cardiomyopathy
• end-diastolic and end-systolic dimensions are significantly increased, with unchanged or decreased wall thickness suggesting cardiomyopathy
• insterstitial cell fibrosis is observed by 4 months of age
• by 4 months, fractional shortening is significantly reduced
• diastolic dysfunction is reduced by 4 months of age
• left ventricular pressure gradient versus time (systolic function) is significantly reduced by 4 months of age

muscle
• myocyte cross-sectional area is increased significantly by 4 months of age
• end-diastolic and end-systolic dimensions are significantly increased, with unchanged or decreased wall thickness suggesting cardiomyopathy
• by 4 months, fractional shortening is significantly reduced
• diastolic dysfunction is reduced by 4 months of age
• left ventricular pressure gradient versus time (systolic function) is significantly reduced by 4 months of age

growth/size/body
• at 2 months, mice show significant increase in heart-to-body weight ratios that increase with age compared to controls
• before 2 months of age, mice exhibit concentric hypertrophic remodeling
• end-diastolic and end-systolic dimensions are significantly increased, with unchanged or decreased wall thickness suggesting cardiomyopathy

cellular
• insterstitial cell fibrosis is observed by 4 months of age





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory