Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Myh6-MEF2A)1Jmol transgene insertion 1, Jeffery D Molkentin MGI:3851584 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cardiac hypertrophy is not enhanced above that observed in Tg(Myh6-MEF2A)1Jmol single transgenic animals
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• cardiac hypertrophy is not enhanced above that observed in Tg(Myh6-MEF2A)1Jmol single transgenic animals
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• medium expressing mice show greater pulmonary congestion measured by lung weight to tibia length compared to controls after 2 weeks of transverse aortic constriction
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• 8-week old medium expressing transgenic mice show a 91% increase in heart weight normalized to tibia length compared to controls after 2 weeks of transverse aortic constriction
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• medium expressing mice have enlarged hearts compared to controls after 2 weeks of transverse aortic constriction
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• 8-week old medium expressing transgenic mice show a 91% increase in heart weight normalized to tibia length compared to controls after 2 weeks of transverse aortic constriction
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• medium expressing mice show greater left ventricle dilation compared to controls after 2 weeks of transverse aortic constriction; mice show more dilation than wild-type and low expressing animals which display concentric hypertrophy
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• medium expressing mice exhibit greater decompensation in ventricular performance compared to controls after 2 weeks of transverse aortic constriction
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• 8-week old medium expressing transgenic mice show a 91% increase in heart weight normalized to tibia length compared to controls after 2 weeks of transverse aortic constriction
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• medium expressing mice exhibit greater decompensation in ventricular performance compared to controls after 2 weeks of transverse aortic constriction
|
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• medium expressing mice show greater pulmonary congestion measured by lung weight to tibia length compared to controls after 2 weeks of transverse aortic constriction
|
|
• medium expressing mice have enlarged hearts compared to controls after 2 weeks of transverse aortic constriction
|
|
• 8-week old medium expressing transgenic mice show a 91% increase in heart weight normalized to tibia length compared to controls after 2 weeks of transverse aortic constriction
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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