Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Mapk8*,Myh6-Mapk9*)22.4Jmol
• Allele Name: transgene insertion 22.4, Jeffery D Molkentin
• Allele ID: MGI:3851796
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Mapk8*,Myh6-Mapk9*)22.4Jmol/0	involves: FVB/N	MGI:3851981

Genotype
MGI:3851981

tg1

• Allelic Composition: Tg(Myh6-Mapk8*,Myh6-Mapk9*)22.4Jmol/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardium layer morphology ( J:102152 )

• after induced ischemia-reperfusion (I-R) injury, mice show significant protection compared to wild-type controls as indicated by reduced viable myocardium area at risk (AAR) versus nonviable infarcted area (IA)

muscle

abnormal myocardium layer morphology ( J:102152 )

• after induced ischemia-reperfusion (I-R) injury, mice show significant protection compared to wild-type controls as indicated by reduced viable myocardium area at risk (AAR) versus nonviable infarcted area (IA)

decreased cardiomyocyte apoptosis ( J:102152 )

• significantly less cleavage of caspase-3 (reduced by about 50%) is observed compared to wild-type

• significant reduction in DNA laddering after I-R injury compared to wild-type

• total apoptosis rate in left ventricle infarcted area is reduced leading to a decrease in the index of cell death

cellular

decreased cardiomyocyte apoptosis ( J:102152 )

• significantly less cleavage of caspase-3 (reduced by about 50%) is observed compared to wild-type

• significant reduction in DNA laddering after I-R injury compared to wild-type

• total apoptosis rate in left ventricle infarcted area is reduced leading to a decrease in the index of cell death