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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hdac8tm1.1Eno
targeted mutation 1.1, Eric N Olson
MGI:3851814
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hdac8tm1.1Eno/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129 * C57BL/6 * CBA * CD-1 MGI:3851920
cn2
 		Hdac8tm1.1Eno/Y
Tg(Col1a1-cre)1Kry/0 		involves: 129 * C57BL/6 * CD-1 * FVB/N MGI:3851915
cn3
 		Hdac8tm1.1Eno/Y
Tg(Col2a1-cre)1Bhr/0 		involves: 129 * C57BL/6 * CD-1 * SJL MGI:3851916
cn4
 		Hdac8tm1.1Eno/Y
Twist2tm1(cre)Dor/Twist2+ 		involves: 129 * C57BL/6 * CD-1 * SJL MGI:3851917
cn5
 		Hdac8tm1.1Eno/Hdac8tm1.1Eno
Tg(Zp3-cre)93Knw/0 		involves: 129S6/SvEvTac * C57BL/6J MGI:6835643
cn6
 		Hdac8tm1.1Eno/Hdac8tm1.2Eno
Tg(Ddx4-cre)1Dcas/0 		involves: 129S6/SvEvTac * C57BL/6J * FVB MGI:6835645


Genotype
MGI:3851920
cn1
Allelic
Composition		 Hdac8tm1.1Eno/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129 * C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (27 available)
Hdac8tm1.1Eno mutation (0 available); any Hdac8 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:150709 )
• some mice die within 4-6 hours after birth from brain hemorrhaging

cardiovascular system
intracranial hemorrhage ( J:150709 )
• some mice die within 4-6 hours after birth from brain hemorrhaging
• hemorrhaging results from ossification defects in the skull

craniofacial
frontal bone foramen ( J:150709 )
• ossification defects lead to the presence of soft tissues in the frontal and interparietal bone

nervous system
intracranial hemorrhage ( J:150709 )
• some mice die within 4-6 hours after birth from brain hemorrhaging
• hemorrhaging results from ossification defects in the skull

skeleton
frontal bone foramen ( J:150709 )
• ossification defects lead to the presence of soft tissues in the frontal and interparietal bone
failure of intramembranous bone ossification ( J:150709 )
• ossification defects lead to the presence of soft tissues in the frontal and interparietal bone and incomplete skull closure




Genotype
MGI:3851915
cn2
Allelic
Composition		 Hdac8tm1.1Eno/Y
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: 129 * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac8tm1.1Eno mutation (0 available); any Hdac8 mutation (10 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:150709 )
• no abnormal phenotype is detected in skull development




Genotype
MGI:3851916
cn3
Allelic
Composition		 Hdac8tm1.1Eno/Y
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: 129 * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac8tm1.1Eno mutation (0 available); any Hdac8 mutation (10 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:150709 )
• no abnormal phenotype is detected in skull development




Genotype
MGI:3851917
cn4
Allelic
Composition		 Hdac8tm1.1Eno/Y
Twist2tm1(cre)Dor/Twist2+
Genetic
Background		 involves: 129 * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac8tm1.1Eno mutation (0 available); any Hdac8 mutation (10 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:150709 )
• no abnormal phenotype is detected in skull development




Genotype
MGI:6835643
cn5
Allelic
Composition		 Hdac8tm1.1Eno/Hdac8tm1.1Eno
Tg(Zp3-cre)93Knw/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac8tm1.1Eno mutation (0 available); any Hdac8 mutation (10 available)
Tg(Zp3-cre)93Knw mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:285736 )
N
• females exhibit normal ovarian histology and follicle counts at 18 days (prepubertal), at 7 weeks, and at 7 months of age, indicating normal folliculogenesis
• when bred with wild type male mice for 6 months, adult females show normal fertility with no significant differences in average litter size or age-associated changes in fertility relative to controls
• fully grown oocytes from hyperstimulated female mice exhibit no changes in oocyte number, germinal vesicle diameter, and nuclear or nucleolar morphology




Genotype
MGI:6835645
cn6
Allelic
Composition		 Hdac8tm1.1Eno/Hdac8tm1.2Eno
Tg(Ddx4-cre)1Dcas/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac8tm1.1Eno mutation (0 available); any Hdac8 mutation (10 available)
Hdac8tm1.2Eno mutation (0 available); any Hdac8 mutation (10 available)
Tg(Ddx4-cre)1Dcas mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:285736 )
N
• females exhibit normal ovarian histology and follicle counts at 18 days (prepubertal) and at 7 months of age, indicating normal folliculogenesis
abnormal oogenesis ( J:285736 )
• reduced female fertility is likely due to subtle defects in oogenesis resulting in smaller oocytes with compromised cytoplasmic competence
abnormal oocyte morphology ( J:285736 )
• fully grown oocytes from hyperstimulated females are significantly smaller than control oocytes, as determined by germinal vesicle diameter
abnormal female meiosis ( J:285736 )
• in vitro oocyte maturation (IVM) analysis revealed that only 80% of germinal vesicle-intact oocytes arrested in prophase of meiosis I are able to resume meiosis and reach metaphase of meiosis I (MI) within 8 h relative to ~90% in controls
• however, spindle morphology and chromosome alignment are normal at the MI stage and no chromosome segregation defects are observed following IVM
reduced female fertility ( J:285736 )
• females show a mild subfertility phenotype
decreased litter size ( J:285736 )
• when bred with wild type male mice for 6 months, adult females produce a significantly lower average litter size than controls

cellular
abnormal oogenesis ( J:285736 )
• reduced female fertility is likely due to subtle defects in oogenesis resulting in smaller oocytes with compromised cytoplasmic competence
abnormal oocyte morphology ( J:285736 )
• fully grown oocytes from hyperstimulated females are significantly smaller than control oocytes, as determined by germinal vesicle diameter
abnormal female meiosis ( J:285736 )
• in vitro oocyte maturation (IVM) analysis revealed that only 80% of germinal vesicle-intact oocytes arrested in prophase of meiosis I are able to resume meiosis and reach metaphase of meiosis I (MI) within 8 h relative to ~90% in controls
• however, spindle morphology and chromosome alignment are normal at the MI stage and no chromosome segregation defects are observed following IVM

embryo
embryo phenotype ( J:285736 )
N
• in culture, the % of zygotes progressing to the blastocyst stage is not significantly different from that in controls, suggesting normal preimplantation embryo development




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory