Phenotypes associated with this allele

• Allele Symbol: Atr^tm1Twgl
• Allele Name: targeted mutation 1, Thomas W Glover
• Allele ID: MGI:3851820
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atr^tm1Twgl/Atr^tm1Twgl	involves: 129S6/SvEvTac * C57BL/6J	MGI:3851909
ht2	Atr^tm1Twgl/Atr^+	involves: 129S6/SvEvTac * C57BL/6J	MGI:3851908

Genotype
MGI:3851909

hm1

• Allelic Composition: Atr^tm1Twgl/Atr^tm1Twgl
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased mitotic index ( J:150723 )

• in fibroblasts following treatment with APH

induced chromosome breakage ( J:150723 )

• fibroblasts treated with 0.4 uM APH exhibit increased chromosomal gaps and breaks compared with similarly treated wild-type cells

• treatment with 0.4 uM APH induces increased chromosomal breakage at common fragile sites compared to in wild-type cells

Genotype
MGI:3851908

ht2

• Allelic Composition: Atr^tm1Twgl/Atr⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

cellular

decreased mitotic index ( J:150723 )

• in fibroblasts following treatment with APH

induced chromosome breakage ( J:150723 )

• fibroblasts treated with 0.4 uM APH exhibit increased chromosomal gaps and breaks compared with similarly treated wild-type cells but not as much as in homozygous cells