Phenotypes associated with this allele

• Allele Symbol: Hr^Hp
• Allele Name: hairpoor
• Allele ID: MGI:3851914
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hr^Hp/Hr^Hp	BALB/cJ-Hr^Hp	MGI:3851927
ht2	Hr^Hp/Hr^+	BALB/cJ-Hr^Hp	MGI:3851928

Genotype
MGI:3851927

hm1

• Allelic Composition: Hr^Hp/Hr^Hp
• Genetic Background: BALB/cJ-Hr^Hp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hair coat abnormalities in Hr^Hp/Hr⁺ and Hr^Hp/Hr^Hp mice

integument

alopecia ( J:150720 )

• as early as P7

abnormal hair shaft morphology ( J:150720 )

• by P21, hair shafts are abnormal

• hair shafts fail to penetrate the skin

abnormal hair follicle morphology ( J:150720 )

• hair follicle abnormalities become more severe with age

• vibrissa hair follicles are normal

abnormal hair follicle dermal papilla morphology ( J:150720 )

• the dermal papilla of the hair follicle is located at the border between subcutis and dermis

abnormal hair follicle inner root sheath morphology ( J:150720 )

• by P21, mice exhibit histomorphologically disrupted inner root sheath

abnormal vibrissa morphology ( J:150720 )

• vibrissa are thinner than normal and lack hair fiber compared to in wild-type mice

• vibrissa are shorter than in wild-type mice

abnormal vibrissa number ( J:150720 )

• fewer

curly vibrissae ( J:150720 )

wavy vibrissae ( J:150720 )

abnormal hair cycle ( J:150720 )

abnormal epidermal layer morphology ( J:150720 )

• epidermal epithelial cell growth is reduced and cavernous sinus is expanded compared to in wild-type mice

epidermal cyst ( J:150720 )

• by P21, mice exhibit eosin-staining cyst-like structures

• at P210, the skin is filled with cysts

wrinkled skin ( J:150720 )

• more severe than in heterozygous mice

thin skin ( J:150720 )

• at P21, skin thickness is reduced

growth/size/body

epidermal cyst ( J:150720 )

• by P21, mice exhibit eosin-staining cyst-like structures

• at P210, the skin is filled with cysts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypotrichosis 4		DOID:0110701	OMIM:146550	J:150720

Genotype
MGI:3851928

ht2

• Allelic Composition: Hr^Hp/Hr⁺
• Genetic Background: BALB/cJ-Hr^Hp

Hair coat abnormalities in Hr^Hp/Hr⁺ and Hr^Hp/Hr^Hp mice

integument

alopecia ( J:150720 )

• mice lose their hair as they age and are bald by 40 weeks

short hair ( J:150720 )

sparse hair ( J:150720 )

abnormal vibrissa follicle morphology ( J:150720 )

• vibrissa hair follicles exhibit an intermediate phenotype

abnormal vibrissa morphology ( J:150720 )

• mice exhibit an intermediate vibrissa phenotype

• vibrissa are shorter than in wild-type mice

abnormal vibrissa number ( J:150720 )

• fewer

wavy vibrissae ( J:150720 )

• slightly

abnormal epidermal layer morphology ( J:150720 )

• epidermal epithelial cell growth is reduced and cavernous sinus is expanded compared to in wild-type mice

epidermal cyst ( J:150720 )

• at P210, mice develop cysts in the skin

wrinkled skin ( J:150720 )

• very mild

growth/size/body

epidermal cyst ( J:150720 )

• at P210, mice develop cysts in the skin