Phenotypes associated with this allele

• Allele Symbol: Zbtb18^tm1Haok
• Allele Name: targeted mutation 1, Haruo Okado
• Allele ID: MGI:3851929
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zbtb18^tm1Haok/Zbtb18^tm1Haok	involves: 129	MGI:5502209
hm2	Zbtb18^tm1Haok/Zbtb18^tm1Haok	involves: 129/Sv * C57BL/6	MGI:3851984

Genotype
MGI:5502209

hm1

• Allelic Composition: Zbtb18^tm1Haok/Zbtb18^tm1Haok
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:196306 )

• of cultured cerebral cortex neurons

abnormal neuron differentiation ( J:196306 )

• cells fail to undergo multipolar-to-bipolar transition

abnormal axon extension ( J:196306 )

• impaired with shorter and thinner axons than in wild-type mice

abnormal neuronal migration ( J:196306 )

• impaired neuronal migration in the developing cerebral cortex

• however, knock-down on Ngn2 rescues migration defect

abnormal neuronal precursor proliferation ( J:196306 )

• increased

abnormal subplate morphology ( J:196306 )

• disorganized

abnormal axon morphology ( J:196306 )

• shorter and thinner than in wild-type mice

increased neuronal precursor cell number ( J:196306 )

• of immature intermediate progenitor cells

cellular

increased neuron apoptosis ( J:196306 )

• of cultured cerebral cortex neurons

abnormal neuron differentiation ( J:196306 )

• cells fail to undergo multipolar-to-bipolar transition

abnormal axon extension ( J:196306 )

• impaired with shorter and thinner axons than in wild-type mice

abnormal neuronal migration ( J:196306 )

• impaired neuronal migration in the developing cerebral cortex

• however, knock-down on Ngn2 rescues migration defect

abnormal neuronal precursor proliferation ( J:196306 )

• increased

Genotype
MGI:3851984

hm2

• Allelic Composition: Zbtb18^tm1Haok/Zbtb18^tm1Haok
• Genetic Background: involves: 129/Sv * C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:150768 )

• mice die shortly after birth of unknown causes

nervous system

abnormal cortical ventricular zone morphology ( J:150768 )

• the ventricular zone expands radially in the cortex compared to in wild-type mice

• at E18.5, the ventricular zone is expanded compared to in wild-type mice

abnormal cerebellar foliation ( J:150768 )

• the cerebellum lacks the typical foliation observed in wild-type mice

abnormal hippocampus morphology ( J:150768 )

• the hippocampal fissure is poorly developed compared to in wild-type mice

• laminar structures of the hippocampus are disorganized compared to in wild-type mice

abnormal hippocampus granule cell layer ( J:150768 )

• absent

abnormal hippocampus pyramidal cell layer ( J:150768 )

• absent

small hippocampus ( J:150768 )

abnormal neocortex morphology ( J:150768 )

• the neocortex is hypoplastic, is reduced in thickness, and contains disorganized layers compared to in wild-type mice

abnormal postnatal subventricular zone morphology ( J:150768 )

• expanded at P0 due to increased cell proliferation

decreased neuron number ( J:150768 )

• the number of mature neurons is decreased in neocortex and hippocampus compared to in wild-type mice

• at E16.5, the number of the subplate neurons is decreased and neurons are displaced compared to in wild-type mice

abnormal neuron physiology ( J:150768 )

• neuron proliferation is increased in the subventricular zone compared to in wild-type mice

• reentry into the cell cycle in the cortex is enhanced compared to in wild-type mice

• unlike in wild-type mice, cell-cycle exit is dominantly impaired in the subventricular and intermediate zones but not the ventricular zone at E16.5

• however, cell-cycle exit of progenitor cells in the cortex is normal

increased neuron apoptosis ( J:150768 )

• in the cortex at E18.5

cellular

increased neuron apoptosis ( J:150768 )

• in the cortex at E18.5