All Phenotypes Tg(Slc6a3-icre)1Fto MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Slc6a3-icre)1Fto
transgene insertion 1, Francois Tronche
MGI:3852083

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(LRRK2R1441C)Djmo}/Gt(ROSA)26Sor^{tm1(LRRK2R1441C)Djmo} Tg(Slc6a3-icre)1Fto/0	involves: 129 * C57BL/6J * FVB/N	MGI:5750683
cn2	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Slc6a3-icre)1Fto/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3852116
tg3	Tg(Slc6a3-icre)1Fto/0	involves: FVB/N	MGI:3770172

Allelic Composition	Gt(ROSA)26Sor^{tm1(LRRK2R1441C)Djmo}/Gt(ROSA)26Sor^{tm1(LRRK2R1441C)Djmo} Tg(Slc6a3-icre)1Fto/0
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(LRRK2*R1441C)Djmo} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Slc6a3-icre)1Fto mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:218456 )

N	• mice do not exhibit abnormalities in the distribution or levels of alpha-synuclein, ubiquitin, tau, glial markers, or autophagy markers or neuronal degeneration in the brain

abnormal dopaminergic neuron morphology ( J:218456 )

• cultured midbrain dopaminergic neurons exhibit an increase in neurite complexity

• dopaminergic neurons from 20-22 month old, but not 5 month old mice, exhibit abnormal nuclei with reduced nuclear circularity

• substantia nigra pars compacta neuronal nuclei exhibit irregular shape and numerous invaginations of the nuclear envelope

• however, mice do not exhibit nigral dopaminergic neuronal loss and have normal dopaminergic nerve terminals in the striatum

behavior/neurological

behavior/neurological phenotype ( J:218456 )

N	• mice exhibit normal motor behaviors in the open field and on the rotarod and normal gait

taste/olfaction

taste/olfaction phenotype ( J:218456 )

N	• mice exhibit normal olfactory function

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Slc6a3-icre)1Fto/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Slc6a3-icre)1Fto mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:150544 )

N	• mutant and control mice show similar acquisition and motivation to self-administer cocaine

nervous system

nervous system phenotype ( J:150544 )

N	• spontaneous activity (firing rates) of dopamine neurons in the ventral tegmental area (VTA) is similar to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:150544 )

N	• circulating glucocorticoid levels are normal under basal and stress conditions

Allelic Composition	Tg(Slc6a3-icre)1Fto/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Slc6a3-icre)1Fto mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:129459 )

N	• mice exhibit normal locomotor, anxiety-like and avoidance behaviors

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