All Phenotypes Fcamr<tm1Shib> MGI Mouse

abnormal memory B cell differentiation ( J:150824 )

• IgG3 production by germinal centers suggests enhanced memory B cell production

• transfer of mutant bone marrow from mice immunized with a T cell-independent antigen produce a higher IgG3 response in hosts upon antigen challenge

• B cells have enhanced affinity-maturation of IgG3 to T cell-independent antigens upon a second challenge

abnormal somatic hypermutation frequency ( J:150824 )

• in recall responses, mice have higher frequencies of somatic hypermutation of the the V-heavy gene segments of antigen-specific IgG3

abnormal spleen germinal center morphology ( J:150824 )

• germinal centers that produce IgG3 result from immunization with a T cell-independent antigen

increased spleen germinal center number ( J:150824 )

• immunization with a T cell-independent antigen causes formation germinal centers that are bigger and more numerous than in controls

increased spleen germinal center size ( J:150824 )

• immunization with a T cell-independent antigen causes formation of germinal centers that are bigger and more numerous than in controls

abnormal marginal zone B cell physiology ( J:150824 )

• marginal zone B cells retain T cell-independent antigen at least 8 hours longer than wild-type controls

abnormal follicular dendritic cell antigen presentation ( J:150824 )

• follicular dendritic cells retain T cell-independent antigen on their cell surface 12 hours after immunization while it is cleared form surface of control cells