Phenotypes associated with this allele

• Allele Symbol: Efna3^tm1Ebp
• Allele Name: targeted mutation 1, Elena B Pasquale
• Allele ID: MGI:3852474
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Efna3^tm1Ebp/Efna3^tm1Ebp	C57BL/6-Efna3^tm1Ebp	MGI:3852495

Genotype
MGI:3852495

hm1

• Allelic Composition: Efna3^tm1Ebp/Efna3^tm1Ebp
• Genetic Background: C57BL/6-Efna3^tm1Ebp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:150784 )

N • mice exhibit normal spatial memory, locomotor activity, sensorimotor responses, motor coordination, anxiety, and depression

impaired contextual conditioning behavior ( J:150784 )

• mice exhibit decreased freezing compared with similarly treated wild-type mice

• however, cued conditioning is normal

abnormal response to novel object ( J:150784 )

• mice spend more time exploring a novel object compared with wild-type mice but fail to exhibit renewed interest when the object is moved unlike wild-type mice

• however, normal response to a novel object is restored when mice are allowed to explore their environment for 30 minutes prior to the introduction of the object

• mice exhibit deficiencies in an object placement test in which the exposure to the context is brief, and context and object have to be assimilated at the same time

nervous system

abnormal hippocampus pyramidal cell morphology ( J:150784 )

• at 7 weeks and 8 months, dendritic spines of CA1 pyramidal neuron are disorganized and elongated compared to in wild-type cells

• dendritic spines exhibit more mushroom-shaped spines and fewer stubby spines compared to in wild-type cells

• however, spine density and width are normal