hematopoietic system
N |
• platelets exhibit normal granule numbers
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• mice exhibit reduced proplatelet-forming megakaryocytes compared with wild-type mice
• however, peripheral platelet counts are normal
|
• slightly
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• slightly
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• platelets exhibit less of a discoid shape compared with wild-type cells
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• especially with low concentrations of collagen or thrombin
• however, platelets exhibit normal aggregation response to exogenous ADP or high concentrations of thrombin or collagen
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• after exposure to PAR4p, platelets fail to release dense granules unlike wild-type cells
• collagen-exposed platelets exhibit a slight reduction in release of dense granules compared with wild-type cells
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homeostasis/metabolism
• especially with low concentrations of collagen or thrombin
• however, platelets exhibit normal aggregation response to exogenous ADP or high concentrations of thrombin or collagen
|
• after exposure to PAR4p, platelets fail to release dense granules unlike wild-type cells
• collagen-exposed platelets exhibit a slight reduction in release of dense granules compared with wild-type cells
|
• no stable plug formation in 8 of 10 mice compared with 2 of 10 wild-type mice
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cellular
• however, peripheral platelet counts are normal
• mice exhibit reduced proplatelet-forming megakaryocytes compared with wild-type mice
|