Phenotypes associated with this allele

• Allele Symbol: Arl8b^{Gt(AK0793)Wtsi}
• Allele Name: gene trap AK0793, Wellcome Trust Sanger Institute
• Allele ID: MGI:3852843
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arl8b^Gt(AK0793)Wtsi/Arl8b^Gt(AK0793)Wtsi	B6J.129P2-Arl8b^Gt(AK0793)Wtsi	MGI:6107944

Genotype
MGI:6107944

hm1

• Allelic Composition: Arl8b^{Gt(AK0793)Wtsi}/Arl8b^{Gt(AK0793)Wtsi}
• Genetic Background: B6J.129P2-Arl8b^{Gt(AK0793)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:245627 )

• die shortly before or just after birth

embryo

decreased embryo size ( J:245627 )

• decreased crown to rump length at E10.5

abnormal visceral yolk sac morphology ( J:245627 )

• the visceral yolk sac is relatively opaque and rough compared to controls at E10.5

• the visceral yolk sac is also opaque at E8.5

abnormal visceral yolk sac endoderm morphology ( J:245627 )

• the cytoplasm of endoderm cells is hypertrophic at E7.5 and E8.5

• the visceral yolk sac endoderm is filled with enlarged vesicular structures that are highly electron dense at E7.5

abnormal extraembryonic tissue physiology ( J:245627 )

• impaired endocytic trafficking to lysosomes in the visceral yolk sac of isolated embryos at E8.5

• protein analysis indicates that endocytosed maternal albumin and IgG accumulate in late endocytic organelles and fail to be degraded in lysosomes in the visceral yolk sac endoderm at E8.5

• maturation of cathepsin L is impaired in the visceral yolk sac endoderm

growth/size/body

decreased embryo size ( J:245627 )

• decreased crown to rump length at E10.5