behavior/neurological
• starting at age 3-4 weeks
|
nervous system
• at ages 4 weeks and 8 months
|
• dilation of distal dendrites at age 4 weeks
|
• reduced length of Ank3-positive region in Purkinje cell axons at age 3 and 4 weeks and 4 months
• increased width of Ank3-positive region in Purkinje cell axons at age 3 and 4 weeks and 4 months
|
• irregular AIS morphology in Purkinje cells at age 3 and 4 weeks: looser microtubule bundles and split towards distal region; lack of continuous, parallel MT bundles
|
• in Purkinje cells at ages 4 weeks and 8 months
|
• Purkinje cell axonal swellings with accumulation of membranous organelles at ages 4 weeks and 8 month
|
mortality/aging
N |
• lifespan
• born at expected Mendelian ratio
|
growth/size/body
• around 20% lower body weight at age 4 weeks
|
reproductive system