Phenotypes associated with this allele

• Allele Symbol: Mtcl1^{Gt(AT0556)Wtsi}
• Allele Name: gene trap AT0556, Wellcome Trust Sanger Institute
• Allele ID: MGI:3853016
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtcl1^Gt(AT0556)Wtsi/Mtcl1^Gt(AT0556)Wtsi	B6.129P2-Mtcl1^Gt(AT0556)Wtsi	MGI:6154041

Genotype
MGI:6154041

hm1

• Allelic Composition: Mtcl1^{Gt(AT0556)Wtsi}/Mtcl1^{Gt(AT0556)Wtsi}
• Genetic Background: B6.129P2-Mtcl1^{Gt(AT0556)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:253309 )

• starting at age 3-4 weeks

nervous system

Purkinje cell degeneration ( J:253309 )

• at ages 4 weeks and 8 months

abnormal Purkinje cell dendrite morphology ( J:253309 )

• dilation of distal dendrites at age 4 weeks

abnormal axon morphology ( J:253309 )

• reduced length of Ank3-positive region in Purkinje cell axons at age 3 and 4 weeks and 4 months

• increased width of Ank3-positive region in Purkinje cell axons at age 3 and 4 weeks and 4 months

abnormal axon initial segment morphology ( J:253309 )

• irregular AIS morphology in Purkinje cells at age 3 and 4 weeks: looser microtubule bundles and split towards distal region; lack of continuous, parallel MT bundles

axon degeneration ( J:253309 )

• in Purkinje cells at ages 4 weeks and 8 months

axonal spheroids ( J:253309 )

• Purkinje cell axonal swellings with accumulation of membranous organelles at ages 4 weeks and 8 month

mortality/aging

mortality/aging ( J:253309 )

N • born at expected Mendelian ratio

N • lifespan

growth/size/body

decreased body weight ( J:253309 )

• around 20% lower body weight at age 4 weeks

reproductive system

female infertility ( J:253309 )

♀