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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		HnrnpabGt(AV0462)Wtsi
gene trap AV0462, Wellcome Trust Sanger Institute
MGI:3853060
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		HnrnpabGt(AV0462)Wtsi/HnrnpabGt(AV0462)Wtsi involves: 129P2/OlaHsd MGI:5770079


Genotype
MGI:5770079
hm1
Allelic
Composition		 HnrnpabGt(AV0462)Wtsi/HnrnpabGt(AV0462)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HnrnpabGt(AV0462)Wtsi mutation (1 available); any Hnrnpab mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased susceptibility to neuronal excitotoxicity ( J:227973 )
• neurons exhibit increased sensitivity to glutamate-induced excitotoxicity compared with wild-type cells
abnormal neuron differentiation ( J:227973 )
• cultured neurospheres exhibit altered differentiation of stem and progenitor cells
abnormal neurite morphology ( J:227973 )
• longer than in wild-type cells

homeostasis/metabolism
increased susceptibility to neuronal excitotoxicity ( J:227973 )
• neurons exhibit increased sensitivity to glutamate-induced excitotoxicity compared with wild-type cells

cellular
increased susceptibility to neuronal excitotoxicity ( J:227973 )
• neurons exhibit increased sensitivity to glutamate-induced excitotoxicity compared with wild-type cells
abnormal neuron differentiation ( J:227973 )
• cultured neurospheres exhibit altered differentiation of stem and progenitor cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory