Phenotypes associated with this allele

• Allele Symbol: Prdm5^{Gt(AV0702)Wtsi}
• Allele Name: gene trap AV0702, Wellcome Trust Sanger Institute
• Allele ID: MGI:3853086
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prdm5^Gt(AV0702)Wtsi/Prdm5^Gt(AV0702)Wtsi	B6.129P2-Prdm5^Gt(AV0702)Wtsi	MGI:5431875

Genotype
MGI:5431875

hm1

• Allelic Composition: Prdm5^{Gt(AV0702)Wtsi}/Prdm5^{Gt(AV0702)Wtsi}
• Genetic Background: B6.129P2-Prdm5^{Gt(AV0702)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced bone formation in Prdm5^{Gt(AV0702)Wtsi}/Prdm5^{Gt(AV0702)Wtsi} mice

skeleton

abnormal bone structure ( J:185118 )

abnormal bone collagen fibril morphology ( J:185118 )

• marked decrease in the presence and organization of collagen fibers in embryonic limbs

decreased bone mineral content ( J:185118 )

• in femurs at 5 weeks of age

• more robust reduction in cortical regions than in trabecular regions

decreased bone mineral density of femur ( J:185118 )

• decreased bone mineral density in femurs at 5 weeks of age

• more robust reduction in cortical regions than in trabecular regions

decreased bone volume ( J:185118 )

• decrease in total bone area in femurs at 5 weeks of age

• more robust reduction in cortical regions than in trabecular regions

decreased compact bone volume ( J:185118 )

decreased trabecular bone volume ( J:185118 )

abnormal osteoblast morphology ( J:185118 )

• shorter osteoblast region at E16.5 in the tibia

delayed bone ossification ( J:185118 )