All Phenotypes Spop<Gt(BGB118)Byg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Spop^{Gt(BGB118)Byg}
gene trap BGB118, BayGenomics
MGI:3853475

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spop^{Gt(BGB118)Byg}/Spop^{Gt(BGB118)Byg}	involves: 129P2/OlaHsd * C57BL/6	MGI:4837257
ht2	Spop^{Gt(BGB118)Byg}/Spop⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4837258
cx3	Pdx1^tm1Cvw/Pdx1⁺ Spop^{Gt(BGB118)Byg}/Spop⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4837259

Allelic Composition	Spop^{Gt(BGB118)Byg}/Spop^{Gt(BGB118)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spop^{Gt(BGB118)Byg} mutation (0 available); any Spop mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:165268 )

• although present at E18.5, no mice are present after P1

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:165268 )

• at E18.5, beta cell area is increased 3-fold compared to in wild-type mice

Allelic Composition	Spop^{Gt(BGB118)Byg}/Spop⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spop^{Gt(BGB118)Byg} mutation (0 available); any Spop mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:165268 )

N	• beta cell size is normal

abnormal pancreatic islet cell apoptosis ( J:165268 )

abnormal pancreatic beta cell physiology ( J:165268 )

• beta cell replication is increased compared to in wild-type mice

• however, beta cell replication and apoptosis are balanced

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:165268 )

N	• mice exhibit normal glucose homeostasis

cellular

abnormal pancreatic islet cell apoptosis ( J:165268 )

Allelic Composition	Pdx1^tm1Cvw/Pdx1⁺ Spop^{Gt(BGB118)Byg}/Spop⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdx1^tm1Cvw mutation (1 available); any Pdx1 mutation (35 available)
Spop^{Gt(BGB118)Byg} mutation (0 available); any Spop mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:165268 )

N	• beta cell mass and the distribution of islet size are normalized unlike in either single heterozygote • mice do not exhibit beta cell apoptosis unlike either single heterozygote

abnormal pancreatic beta cell morphology ( J:165268 )

• beta cell size is decreased compared to in wild-type mice or either single heterozygote

disorganized pancreatic islets ( J:165268 )

abnormal pancreatic beta cell physiology ( J:165268 )

• endoplasmic reticulum stress is reduced compared to in Pdx1^tm1Cvw heterozygote

• beta cell replication is increased compared to in wild-type mice

decreased insulin secretion ( J:165268 )

• glucose-stimulated insulin secretion is reduced compared to in wild-type mice but not as severely as in Pdx1^tm1Cvw heterozygote

homeostasis/metabolism

decreased insulin secretion ( J:165268 )

• glucose-stimulated insulin secretion is reduced compared to in wild-type mice but not as severely as in Pdx1^tm1Cvw heterozygote

increased circulating glucose level ( J:165268 )

improved glucose tolerance ( J:165268 )

• compared with Pdx1^tm1Cvw heterozygote

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24