Phenotypes associated with this allele

• Allele Symbol: Gnrhr^{Gt(181A6)Cmhd}
• Allele Name: gene trap 181A6, Centre for Modeling Human Disease
• Allele ID: MGI:3855285
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnrhr^Gt(181A6)Cmhd/Gnrhr^Gt(181A6)Cmhd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4439394

Genotype
MGI:4439394

hm1

• Allelic Composition: Gnrhr^{Gt(181A6)Cmhd}/Gnrhr^{Gt(181A6)Cmhd}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal spermatocyte morphology ( J:158384 )

♂ • abnormal appearance young spermatocytes and possibly degenerating central mass of cells at 15.5 postnatal days

growth/size/body

increased body weight ( J:158384 )

• increased body weight in female after 6 months of age

• normal body weight in female up to 60 postnatal days

• normal body weight in male

reproductive system

abnormal spermatocyte morphology ( J:158384 )

♂ • abnormal appearance young spermatocytes and possibly degenerating central mass of cells at 15.5 postnatal days

abnormal internal female genitalia morphology ( J:158384 )

♀

abnormal ovary morphology ( J:158384 )

♀

absent corpus luteum ( J:158384 )

♀ • absence of corpora lutea at 2 months

increased atretic ovarian follicle number ( J:158384 )

♀ • many atretic follicles at 2 months

impaired ovarian folliculogenesis ( J:158384 )

♀ • follicles advance only rarely to the early antral stage at 2 months

decreased ovary weight ( J:158384 )

♀ • decreased ovaries weight in 2-month-old mice (23% of those of sex matched wild-type littermates)

thin uterus ( J:158384 )

♀ • thread-like uterus

constricted vagina orifice ( J:158384 )

♀ • pin point openings

abnormal external male genitalia morphology ( J:158384 )

♂ • reduced anal-genital distance in male

small male preputial gland ( J:158384 )

♂ • reduced size of the preputial gland

small penis ( J:158384 )

♂ • small genital papilla in male

abnormal internal male genitalia morphology ( J:158384 )

♂

small seminal vesicle ( J:158384 )

♂ • reduced size of the androgen-dependent seminal vesicle

abnormal testis morphology ( J:158384 )

♂

abnormal seminiferous tubule morphology ( J:158384 )

♂ • a central mass of cells is difficult to identify and many are possibly degenerating at 10.5 postnatal days

♂ • the smaller cord contains a peripheral layer of Sertoli cell nuclei and spermatogonia at 10.5 and 15.5 postnatal days

♂ • no lumen formation at 15.5 postnatal days and 2 months of age

♂ • testosterone-treated null males (n=3) have elongated spermatids and a lumen

small seminiferous tubules ( J:158384 )

♂ • smaller cord starting from 10.5 postnatal days

small testis ( J:158384 )

♂ • smaller testis starting from 10.5 postnatal days

decreased testis weight ( J:158384 )

♂ • decreased testis weight in 2-month-old mutants (only 3% of those of wild-type littermates)

♂ • testosterone-treated null males (n=3) have testes weight increased to 54% of sham implanted WT males (n=4)

small epididymis ( J:158384 )

♂ • reduced size of the epididymis

delayed vaginal opening ( J:158384 )

• delayed vaginal opening (41.4 vs 34.6)

• in about 25%of null mice, the vagina is not open even by 6 months of age

abnormal female reproductive system physiology ( J:158384 )

♀

absent estrous cycle ( J:158384 )

♀ • no estrous cycles

female infertility ( J:158384 )

♀

male infertility ( J:158384 )

♂

homeostasis/metabolism

decreased circulating testosterone level ( J:158384 )

• decreased serum testosterone level in male (0.1 vs 0.7 ng/ml)

decreased circulating estradiol level ( J:158384 )

• decreased serum estradiol level in female (10.0 vs 30.7 pg/ml)

decreased circulating follicle stimulating hormone level ( J:158384 )

• decreased serum FSH level in male (3.4 vs 33.5 ng/ml) and female (2.3 vs 8.0 ng/ml)

decreased circulating luteinizing hormone level ( J:158384 )

• undetectable serum LH levels in male and female (<0.048 ng/ml)

decreased circulating progesterone level ( J:158384 )

• decreased serum progesterone level in female (3.2 vs 9.4 ng/ml)

renal/urinary system

small male preputial gland ( J:158384 )

♂ • reduced size of the preputial gland

small penis ( J:158384 )

♂ • small genital papilla in male

endocrine/exocrine glands

small male preputial gland ( J:158384 )

♂ • reduced size of the preputial gland

small seminal vesicle ( J:158384 )

♂ • reduced size of the androgen-dependent seminal vesicle

abnormal ovary morphology ( J:158384 )

♀

absent corpus luteum ( J:158384 )

♀ • absence of corpora lutea at 2 months

increased atretic ovarian follicle number ( J:158384 )

♀ • many atretic follicles at 2 months

impaired ovarian folliculogenesis ( J:158384 )

♀ • follicles advance only rarely to the early antral stage at 2 months

decreased ovary weight ( J:158384 )

♀ • decreased ovaries weight in 2-month-old mice (23% of those of sex matched wild-type littermates)

abnormal testis morphology ( J:158384 )

♂

abnormal seminiferous tubule morphology ( J:158384 )

♂ • a central mass of cells is difficult to identify and many are possibly degenerating at 10.5 postnatal days

♂ • the smaller cord contains a peripheral layer of Sertoli cell nuclei and spermatogonia at 10.5 and 15.5 postnatal days

♂ • no lumen formation at 15.5 postnatal days and 2 months of age

♂ • testosterone-treated null males (n=3) have elongated spermatids and a lumen

small seminiferous tubules ( J:158384 )

♂ • smaller cord starting from 10.5 postnatal days

small testis ( J:158384 )

♂ • smaller testis starting from 10.5 postnatal days

decreased testis weight ( J:158384 )

♂ • decreased testis weight in 2-month-old mutants (only 3% of those of wild-type littermates)

♂ • testosterone-treated null males (n=3) have testes weight increased to 54% of sham implanted WT males (n=4)

integument

small male preputial gland ( J:158384 )

♂ • reduced size of the preputial gland