Phenotypes associated with this allele

• Allele Symbol: Gga1^{Gt(AN0619)Wtsi}
• Allele Name: gene trap AN0619, Wellcome Trust Sanger Institute
• Allele ID: MGI:3856874
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gga1^Gt(AN0619)Wtsi/Gga1^Gt(AN0619)Wtsi	B6J.129P2-Gga1^Gt(AN0619)Wtsi	MGI:5424777
cx2	Gga1^Gt(AN0619)Wtsi/Gga1^Gt(AN0619)Wtsi Gga3^Gt(RRC067)Byg/Gga3^Gt(RRC067)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:5424779
cx3	Gga1^Gt(AN0619)Wtsi/Gga1^+ Gga3^Gt(RRC067)Byg/Gga3^Gt(RRC067)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:5424780

Genotype
MGI:5424777

hm1

• Allelic Composition: Gga1^{Gt(AN0619)Wtsi}/Gga1^{Gt(AN0619)Wtsi}
• Genetic Background: B6J.129P2-Gga1^{Gt(AN0619)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased birth weight ( J:184229 )

slow postnatal weight gain ( J:184229 )

• gained weight somewhat slower than controls

mortality/aging

neonatal lethality, incomplete penetrance ( J:184229 )

• 9% neonatal lethality

homeostasis/metabolism

hypoglycemia ( J:184229 )

• exhibit hypoglycemia on postnatal day 1

abnormal circulating enzyme level ( J:184229 )

• a marginal elevation (1.6 to 2.2 fold) in plasma levels of a subset of the acid hydrolases

Genotype
MGI:5424779

cx2

• Allelic Composition: Gga1^{Gt(AN0619)Wtsi}/Gga1^{Gt(AN0619)Wtsi}; Gga3^{Gt(RRC067)Byg}/Gga3^{Gt(RRC067)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

growth/size/body

decreased birth weight ( J:184229 )

slow postnatal weight gain ( J:184229 )

• gained weight even more slowly than the single nulls, and at 20 weeks exhibited a 38% reduction in weight compared to controls

mortality/aging

neonatal lethality, incomplete penetrance ( J:184229 )

• 47% neonatal lethality

postnatal lethality, incomplete penetrance ( J:184229 )

reproductive system

reduced fertility ( J:184229 )

• adult survivors have a normal lifespan but exhibit extremely poor fertility

homeostasis/metabolism

hypoglycemia ( J:184229 )

• exhibit hypoglycemia on postnatal day 1

abnormal circulating enzyme level ( J:184229 )

• a marginal elevation (1.6 to 2.2 fold) in plasma levels of a subset of the acid hydrolases

Genotype
MGI:5424780

cx3

• Allelic Composition: Gga1^{Gt(AN0619)Wtsi}/Gga1⁺; Gga3^{Gt(RRC067)Byg}/Gga3^{Gt(RRC067)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

neonatal lethality, incomplete penetrance ( J:184229 )

• increased neonatal mortality, but half the rate of double homozygous mice