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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Esyt2Gt(AN0678)Wtsi
gene trap AN0678, Wellcome Trust Sanger Institute
MGI:3856884
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Esyt2Gt(AN0678)Wtsi/Esyt2Gt(AN0678)Wtsi involves: 129P2/OlaHsd MGI:5896569
cx2
 		Esyt2Gt(AN0678)Wtsi/Esyt2Gt(AN0678)Wtsi
Esyt3tm1d(EUCOMM)Wtsi/Esyt3tm1d(EUCOMM)Wtsi 		involves: 129P2/OlaHsd * C57BL/6N MGI:5896572


Genotype
MGI:5896569
hm1
Allelic
Composition		 Esyt2Gt(AN0678)Wtsi/Esyt2Gt(AN0678)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esyt2Gt(AN0678)Wtsi mutation (1 available); any Esyt2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:232605 )
N
• mice are viable and fertile without overt morphological defects

cellular
decreased cell migration ( J:232605 )
• of FGF-stimulated mouse embryonic fibroblasts




Genotype
MGI:5896572
cx2
Allelic
Composition		 Esyt2Gt(AN0678)Wtsi/Esyt2Gt(AN0678)Wtsi
Esyt3tm1d(EUCOMM)Wtsi/Esyt3tm1d(EUCOMM)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Cell Lines EPD0458_5_A10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esyt2Gt(AN0678)Wtsi mutation (1 available); any Esyt2 mutation (43 available)
Esyt3tm1d(EUCOMM)Wtsi mutation (1 available); any Esyt3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:232605 )
• fewer than expected mice are born
• however, surviving mice exhibit normal development, viability, survival, reproduction and organ development (lung, testis and spleen)

cellular
increased sensitivity to induced cell death ( J:232605 )
• mouse embryonic fibroblasts are less resistance to FGF serum withdrawal compared with control cells
increased cellular sensitivity to oxidative stress ( J:232605 )
• in mouse embryonic fibroblasts
decreased cell migration ( J:232605 )
• of FGF-stimulated mouse embryonic fibroblasts




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory