mortality/aging
• no live embryos after E10.5
|
growth/size/body
• smaller than controls at E9.5
|
embryo
N |
• nodal cilia are functional
|
• almost never complete
|
• smaller than controls at E9.5
|
• reduced cell-cell contacts
• poorly organized microvilli and apical vacuoles are missing
• bulbous misshapen microvilli frequently observed with small vescicles
|