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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Epm2aip1Gt(BA0314)Wtsi
gene trap BA0314, Wellcome Trust Sanger Institute
MGI:3857785
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Epm2aip1Gt(BA0314)Wtsi/Epm2aip1Gt(BA0314)Wtsi involves: 129P2/OlaHsd * C57BL/6 MGI:5563527


Genotype
MGI:5563527
hm1
Allelic
Composition
Epm2aip1Gt(BA0314)Wtsi/Epm2aip1Gt(BA0314)Wtsi
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epm2aip1Gt(BA0314)Wtsi mutation (0 available); any Epm2aip1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• during a clamp experiment, mice exhibit complete failure of endogenous glucose production suppression, indicating hepatic insulin resistance, compared with wild-type mice
• however, mice exhibit normal insulin tolerance
• during a clamp experiment, mice exhibit complete failure of endogenous glucose production suppression, indicating hepatic insulin resistance, compared with wild-type mice
• in a glucose tolerance test, glucose clearance is increased compared with wild-type mice
• reduced hepatic glycogen synthesis

behavior/neurological
N
• mice do not exhibit epilepsy, motor deficits and ataxia
• in open field and startle tests

growth/size/body

liver/biliary system

muscle
N
• skeletal muscle exhibits normal glycogen storage with no lipid accumulation





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory