homeostasis/metabolism
• during a clamp experiment, mice exhibit complete failure of endogenous glucose production suppression, indicating hepatic insulin resistance, compared with wild-type mice
• however, mice exhibit normal insulin tolerance
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• in fasted mice
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• during a clamp experiment, mice exhibit complete failure of endogenous glucose production suppression, indicating hepatic insulin resistance, compared with wild-type mice
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• in a glucose tolerance test, glucose clearance is increased compared with wild-type mice
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• reduced hepatic glycogen synthesis
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behavior/neurological
N |
• mice do not exhibit epilepsy, motor deficits and ataxia
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• in open field and startle tests
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growth/size/body
• in adulthood
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liver/biliary system
muscle
N |
• skeletal muscle exhibits normal glycogen storage with no lipid accumulation
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