All Phenotypes Mcm2<Gt(AB0178)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mcm2^{Gt(AB0178)Wtsi}
gene trap AB0178, Wellcome Trust Sanger Institute
MGI:3863806

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcm2^{Gt(AB0178)Wtsi}/Mcm2^{Gt(AB0178)Wtsi}	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838119
ht2	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838118
cx3	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838120
cx4	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838121
cx5	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838122
cx6	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838123
cx7	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838124
cx8	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838127
cx9	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838125
cx10	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838137
cx11	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838107
cx12	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838110

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2^{Gt(AB0178)Wtsi}
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:165667 )

• no viable mice are present at birth

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)
Mcm7^{Gt(YTA285)Byg} mutation (0 available); any Mcm7 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (43 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (43 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)
Mcm7^{Gt(YTA285)Byg} mutation (0 available); any Mcm7 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)
Mcm4^chaos3 mutation (1 available); any Mcm4 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:165667 )

• mice begin to die at 2 months and all mice die by 7 months of age

postnatal lethality ( J:165667 )

• fewer than expected mice are produced (no time point given)

neoplasm

increased tumor incidence ( J:165667 )

• mice exhibit lymphomas/leukemias

• three-quarters of mice develop tumors by 18 months

increased T cell derived lymphoma incidence ( J:165667 )

increased leukemia incidence ( J:165667 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:165667 )

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice and Mcm4^chaos3 homozygotes

reticulocytosis ( J:165667 )

• mice exhibit an increase in the number of CD71+ (proliferating cells, reticulocytes, erythroid precursors) cells compared with Mcm4^chaos3 homozygotes

cellular

decreased fibroblast proliferation ( J:165667 )

• in mouse embryonic fibroblasts after 5 days in culture

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice and Mcm4^chaos3 homozygotes

embryo

abnormal pluripotent precursor cell morphology ( J:165667 )

• mouse embryonic fibroblasts exhibit compromised ability to form induced pluripotent stem cells compared with Mcm4^chaos3 homozygous cells

growth/size/body

decreased body weight ( J:165667 )

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:165667 )

immune system

increased T cell derived lymphoma incidence ( J:165667 )

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:165667 )

• lifespan is expanded compared to in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice but all mice die by 12 months of age

postnatal lethality, incomplete penetrance ( J:165667 )

• mortality observed in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice is largely rescued

neoplasm

increased tumor incidence ( J:165667 )

• onset of tumorigenesis (lymphoma, thymoma, bone tumors, and liver tumors) is delayed or eliminated compared with Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice

hematopoietic system

hematopoietic system phenotype ( J:165667 )

N	• the ratio of CD71+ reticulocytes to total red blood cells is completely corrected compared to in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4^chaos3 homozygotes

cellular

decreased fibroblast proliferation ( J:165667 )

• mouse embryonic fibroblast proliferation (MEFs) is partially rescued compared to in Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 MEFs

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4^chaos3 homozygotes

embryo

abnormal pluripotent precursor cell morphology ( J:165667 )

• mouse embryonic fibroblasts exhibit compromised ability to form induced pluripotent stem cells compared with Mcm4^chaos3/Mcm4^chaos3 cells but improved 2.5- to 10-fold compared with Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 cells

growth/size/body

growth/size/body region phenotype ( J:165667 )

N	• body weight is rescued compared with Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^chaos3/Mcm4^chaos3 mice

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