Analysis Tools
mortality/aging
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• although homozygotes are present at normal Mendelian ratios at E10.5, only 5% (versus expected 25%) are found at E13.5 and no viable homozygotes are recovered at birth
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homeostasis/metabolism
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• pericardial bleeding is noted by E11.5
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cardiovascular system
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• at E10.5, areas of unilateral narrowing of the dorsal aorta are commonly observed
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• at E10.5, cranial blood vessels show a severe reduction in truncal vessels connected to distal capillary networks
• at E11.5, venous vasculature is significantly altered with ectatic dilations noted in the head
• however, cephalic arterial vessels are normal at E10.5
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• at E11.5, embryos exhibit abnormal venous vasculature with ectatic dilations in the head
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• at E11.5, embryos exhibit abnormal venous vasculature with ectatic dilations in the head
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• focal myocardial wall necrosis is noted by E11.5
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• all embryos exhibit small hypoplastic hearts at E10.5 and at later stages
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• at E10.5, hearts show a significant reduction in mRNA expression of two Notch target genes (Hey1 and Hey2), indicating altered Notch signaling
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hemorrhage
(
J:230747
)
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• embryos eventually develop widespread hemorrhages that are apparent by E11.5 and at later stages
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• pericardial bleeding is noted by E11.5
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• neural tube edema is followed by punctate hemorrhages starting in the head at E11.5
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• at E11.5
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nervous system
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• neural tube edema is followed by punctate hemorrhages starting in the head at E11.5
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• at E11.5
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• at E10.5, embryo display neural tube edema
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embryo
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• at E10.5, embryo display neural tube edema
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muscle
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• focal myocardial wall necrosis is noted by E11.5
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