Phenotypes associated with this allele

• Allele Symbol: Dscaml1^{Gt(CC0772)Wtsi}
• Allele Name: gene trap CC0772, Wellcome Trust Sanger Institute
• Allele ID: MGI:3864487
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dscaml1^Gt(CC0772)Wtsi/Dscaml1^Gt(CC0772)Wtsi	involves: 129P2/OlaHsd * C57BL/6J	MGI:4417834
cx2	Dscam^del17/Dscam^del17 Dscaml1^Gt(CC0772)Wtsi/Dscaml1^Gt(CC0772)Wtsi	involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J	MGI:4417835

Genotype
MGI:4417834

hm1

• Allelic Composition: Dscaml1^{Gt(CC0772)Wtsi}/Dscaml1^{Gt(CC0772)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:155397 )

• Background Sensitivity: 50% of mice do not survive weaning when mice are backcrossed to C57BL/6 mice for three generations

vision/eye

abnormal retina morphology ( J:155397 )

• fewer synaptic ribbons and floating ribbons are observed in the retinal unlike in wild-type mice

• however, mosaic patterning of amacrine and retinal ganglion cell types is normal

abnormal amacrine cell morphology ( J:155397 )

• the vertical soma organization of All amacrine cells is disorganized compared to in wild-type mice

• All amacrine cell bodies adhere and aggregate in clumps unlike in wild-type mice

• DA amacrine cell neurites are directed towards clumps of All amacrine cells unlike in wild-type mice

increased amacrine cell number ( J:155397 )

• All amacrine cells are increased in number compared to in wild-type mice

• DA amacrine cells are increased compared to in wild-type mice

abnormal retina rod bipolar cell morphology ( J:155397 )

• rod bipolar cell proximal dendrites exhibit adhesion compared to in wild-type mice

• the number of rod bipolar cells is increased compared to in wild-type mice

• dendrites of rod bipolar cells exhibit less far than in wild-type mice

abnormal retina ganglion layer morphology ( J:155397 )

• retinal ganglion cell soma spacing is disrupted compared to in wild-type mice

• soma aggregation and neurite fasciculation occurs between cells of the same type

abnormal retina ganglion cell morphology ( J:155397 )

• dendrite arborization of retinal ganglion cells (RGCs) is disrupted compared to in wild-type mice

• dendrites of RGCs possess thick fascicles unlike in wild-type mice

abnormal retina inner nuclear layer morphology ( J:155397 )

• increased width

thick retina inner plexiform layer ( J:155397 )

• the retinal inner plexiform layer is expanded compared to in wild-type mice

• All and retinal bipolar cells costratify in the ON portion of the inner plexiform layer forming a dyad synapse unlike in wild-type mice

• synaptic ribbons are not as well formed in the bipolar terminal and have an over abundance of vesicles compared to in wild-type mice

abnormal retina outer plexiform layer morphology ( J:155397 )

• dense fascicles devoid of synaptic vesicles in the outer plexiform layer unlike in wild-type mice

• as early as P9 and P15, the number of ribbon synapses observed in the outer plexiform layer are decreased compared to in wild-type mice

• the number of synapses between rods and retinal bipolar cells is decreased compared to in wild-type mice

nervous system

abnormal amacrine cell morphology ( J:155397 )

• the vertical soma organization of All amacrine cells is disorganized compared to in wild-type mice

• All amacrine cell bodies adhere and aggregate in clumps unlike in wild-type mice

• DA amacrine cell neurites are directed towards clumps of All amacrine cells unlike in wild-type mice

increased amacrine cell number ( J:155397 )

• All amacrine cells are increased in number compared to in wild-type mice

• DA amacrine cells are increased compared to in wild-type mice

abnormal retina rod bipolar cell morphology ( J:155397 )

• rod bipolar cell proximal dendrites exhibit adhesion compared to in wild-type mice

• the number of rod bipolar cells is increased compared to in wild-type mice

• dendrites of rod bipolar cells exhibit less far than in wild-type mice

abnormal retina ganglion cell morphology ( J:155397 )

• dendrite arborization of retinal ganglion cells (RGCs) is disrupted compared to in wild-type mice

• dendrites of RGCs possess thick fascicles unlike in wild-type mice

abnormal excitatory postsynaptic currents ( J:155397 )

• the decay of excitatory postsynaptic currents in All retinal bipolar cell synapses is slower than in wild-type mice

Genotype
MGI:4417835

cx2

• Allelic Composition: Dscam^del17/Dscam^del17; Dscaml1^{Gt(CC0772)Wtsi}/Dscaml1^{Gt(CC0772)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

vision/eye

abnormal retina morphology ( J:155397 )

• retinas are extremely disorganized compared to in wild-type mice

• the number of cells in the retina is increased compared to in wild-type mice

• however, some degree of costratification is maintained

• dendrite fascicles are observed in the outer nuclear portion of the retina unlike in wild-type mice

abnormal retina bipolar cell morphology ( J:155397 )

• retinal bipolar cell axons exhibit varicosities unlike in wild-type mice

abnormal retina ganglion layer morphology ( J:155397 )

• paired cholinergic and alpha retinal ganglion cell bands are not as compact as in wild-type mice

abnormal retina inner nuclear layer morphology ( J:155397 )

• a small number of cholinergic amacrine cell neuritis are laminated in an ectopic plexiform layer within the inner nuclear layer unlike in wild-type mice

• All amacrine cells stratify neuritis in an ectopic plexiform layer within the inner nuclear layer and project neurites past retinal bipolar cell terminals towards the retinal ganglion layer unlike in wild-type mice

nervous system

abnormal retina bipolar cell morphology ( J:155397 )

• retinal bipolar cell axons exhibit varicosities unlike in wild-type mice