Phenotypes associated with this allele

• Allele Symbol: Ero1b^{Gt(P077G11)Wrst}
• Allele Name: gene trap P077G11, German Gene Trap Consortium
• Allele ID: MGI:3864866
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ero1b^Gt(P077G11)Wrst/Ero1b^Gt(P077G11)Wrst	involves: 129S2/SvPas * C57BL/6	MGI:4441482
ht2	Ero1b^Gt(P077G11)Wrst/Ero1b^+	involves: 129S2/SvPas * C57BL/6	MGI:4441479
cx3	Ero1a^Gt(XST171)Byg/Ero1a^Gt(XST171)Byg Ero1b^Gt(P077G11)Wrst/Ero1b^Gt(P077G11)Wrst	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:4441478
cx4	Ero1b^Gt(P077G11)Wrst/Ero1b^+ Ins2^Akita/Ins2^+	involves: 129S2/SvPas * C57BL/6NSlc	MGI:4441480

Genotype
MGI:4441482

hm1

• Allelic Composition: Ero1b^{Gt(P077G11)Wrst}/Ero1b^{Gt(P077G11)Wrst}
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Diminished insulin stores and mildly disorganized islets in Ero1b^{Gt(P077G11)Wrst}/Ero1b^{Gt(P077G11)Wrst} mice

homeostasis/metabolism

abnormal glucose homeostasis ( J:158805 )

• mice exhibit an elevation in the glucose to insulin ratio compared with wild-type mice

decreased insulin secretion ( J:158805 )

• in the pancreas

increased circulating glucose level ( J:158805 )

• in fasting mice by 3 months of age

impaired glucose tolerance ( J:158805 )

endocrine/exocrine glands

disorganized pancreatic islets ( J:158805 )

• with glucagon+ cells at the center

decreased insulin secretion ( J:158805 )

• in the pancreas

Genotype
MGI:4441479

ht2

• Allelic Composition: Ero1b^{Gt(P077G11)Wrst}/Ero1b⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

homeostasis/metabolism

abnormal glucose homeostasis ( J:158805 )

• mice exhibit an elevation in the glucose to insulin ratio compared with wild-type mice

decreased insulin secretion ( J:158805 )

• in the pancreas

increased circulating glucose level ( J:158805 )

impaired glucose tolerance ( J:158805 )

endocrine/exocrine glands

decreased insulin secretion ( J:158805 )

• in the pancreas

Genotype
MGI:4441478

cx3

• Allelic Composition: Ero1a^{Gt(XST171)Byg}/Ero1a^{Gt(XST171)Byg}; Ero1b^{Gt(P077G11)Wrst}/Ero1b^{Gt(P077G11)Wrst}
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

homeostasis/metabolism

impaired glucose tolerance ( J:158805 )

• as in Ero1lb^{Gt(P077G11)Wrst} homozygotes

Genotype
MGI:4441480

cx4

• Allelic Composition: Ero1b^{Gt(P077G11)Wrst}/Ero1b⁺; Ins2^Akita/Ins2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6NSlc

homeostasis/metabolism

decreased insulin secretion ( J:158805 )

• in the pancreas

increased circulating glucose level ( J:158805 )

• plasma glucose levels are higher than in Ins2^Akita heterozygotes

impaired glucose tolerance ( J:158805 )

• glucose intolerance is worse than in Ins2^Akita heterozygotes

endocrine/exocrine glands

small pancreatic islets ( J:158805 )

decreased insulin secretion ( J:158805 )

• in the pancreas