Phenotypes associated with this allele

• Allele Symbol: Glmp^{Gt(P084H04)Wrst}
• Allele Name: gene trap P084H04, German Gene Trap Consortium
• Allele ID: MGI:3865377
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glmp^Gt(P084H04)Wrst/Glmp^Gt(P084H04)Wrst	involves: 129S2/SvPas	MGI:6379243
hm2	Glmp^Gt(P084H04)Wrst/Glmp^Gt(P084H04)Wrst	involves: 129S2/SvPas * C57BL/6	MGI:5574468

Genotype
MGI:6379243

hm1

• Allelic Composition: Glmp^{Gt(P084H04)Wrst}/Glmp^{Gt(P084H04)Wrst}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal liver morphology ( J:280713 )

• liver exhibits a tuberous appearance with uneven surface

• livers show local foci where hepatocytes are lost

abnormal liver vasculature morphology ( J:280713 )

• sites of liver injury show increased formation of new capillaries and a pro-thrombotic status

abnormal liver sinusoidal endothelial cell morphology ( J:280713 )

• liver sinusoid endothelial cells are replaced by ordinary capillary endothelium

abnormal hepatocyte morphology ( J:280713 )

• livers show local foci with hepatocyte loss

cardiovascular system

abnormal liver vasculature morphology ( J:280713 )

• sites of liver injury show increased formation of new capillaries and a pro-thrombotic status

abnormal liver sinusoidal endothelial cell morphology ( J:280713 )

• liver sinusoid endothelial cells are replaced by ordinary capillary endothelium

Genotype
MGI:5574468

hm2

• Allelic Composition: Glmp^{Gt(P084H04)Wrst}/Glmp^{Gt(P084H04)Wrst}
• Genetic Background: involves: 129S2/SvPas * C57BL/6

Inflammation, dying hepatocytes and collagen deposition in Glmp^{Gt(P084H04)Wrst}/Glmp^{Gt(P084H04)Wrst} liver

mortality/aging

mortality/aging ( J:208774 )

N • liver fibrosis does not progress to a lethal condition at up to 18 months of age

reproductive system

reproductive system phenotype ( J:208774 )

N • similar litter sizes and frequency as controls

pigmentation

lipofuscinosis ( J:208774 )

• in Kupffer cells

liver/biliary system

abnormal Kupffer cell morphology ( J:208774 )

• enlarged lysosomes containing lipofuscin and iron

increased liver iron level ( J:208774 )

• in lysosomes in Kupffer cells

liver fibrosis ( J:208774 )

• at 6 months, with large nodules on the surface while maintaining normal liver to body weight ratio

• does not progress to a lethal condition at up to 18 months of age

• widespread deposition of collagen and thick collagen fibers detected at 6 months of age

abnormal liver physiology ( J:208774 )

• increased oxidative stress

liver inflammation ( J:208774 )

• infiltration of mononuclear leukocytes and granulocytes in the portal areas at 6 months of age

abnormal hepatocyte physiology ( J:208774 )

• inflammation and dying hepatocytes at 6 months of age

• scattered acidophilic hepatocytes

increased hepatocyte apoptosis ( J:208774 )

• at 6 months of age

hematopoietic system

abnormal Kupffer cell morphology ( J:208774 )

• enlarged lysosomes containing lipofuscin and iron

increased spleen weight ( J:208774 )

• double the weight of wild-type at 6 months

• likely secondary to liver fibrosis

immune system

abnormal Kupffer cell morphology ( J:208774 )

• enlarged lysosomes containing lipofuscin and iron

increased spleen weight ( J:208774 )

• double the weight of wild-type at 6 months

• likely secondary to liver fibrosis

liver inflammation ( J:208774 )

• infiltration of mononuclear leukocytes and granulocytes in the portal areas at 6 months of age

cellular

abnormal lysosome morphology ( J:208774 )

• enlarged in Kupffer cells

increased hepatocyte apoptosis ( J:208774 )

• at 6 months of age

oxidative stress ( J:208774 )

• in liver

homeostasis/metabolism

increased circulating alanine transaminase level ( J:208774 )

• at 6 months

increased circulating aspartate transaminase level ( J:208774 )

• at 6 months

increased liver iron level ( J:208774 )

• in lysosomes in Kupffer cells

cardiovascular system

abnormal Kupffer cell morphology ( J:208774 )

• enlarged lysosomes containing lipofuscin and iron

growth/size/body

increased spleen weight ( J:208774 )

• double the weight of wild-type at 6 months

• likely secondary to liver fibrosis