Analysis Tools
mortality/aging
|
• most mice die immediately after birth
• mice that survive past birth have a normal life span
|
reproductive system
| N |
• females display cyclic changes in vaginal impedance indicative of normal estrus cycles
|
 |
• sharp decrease in the number of oocytes detected at birth
|
 |
• absent at 3 weeks of age
|
|
|
• decreased number of spermatocytes at 2 weeks of age
|
|
|
• decreased number of spermatogonia at 2 weeks of age
|
|
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• at 6 weeks of age seminiferous tubules are almost completely devoid of germ cells
• in older males the seminiferous tubules are completely devoid of germ cells
|
azoospermia
(
J:173615
)
|
|
• absence of sperm in the epididymal duct lumen at 6 weeks of age
|
|
|
• at 2 weeks of age fewer spermatocytes entering meiosis are detected in the seminiferous tubules
|
|
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• expression analysis indicates spermatogenesis is arrested around the late pachytene/diplotene stages of meiotic prophase I
|
|
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• at 3 weeks of age large numbers of apoptotic germ cells are seen
• the few germ cells present at 6 weeks of age are undergoing apoptosis
|
|
|
• at P8 tubules show only sparse and significantly reduced proliferation of spermatogonia
|
|
|
• at 7 - 8 weeks of age ovaries contain only a few follicles
• at 7 months of age ovaries are devoid of follicles
|
|
|
• detectable at 3 weeks of age with very few follicles present at 2 months of age
|
small ovary
(
J:173615
)
|
|
• strikingly smaller at 2 months of age
|
ovary cyst
(
J:173615
)
|
|
• seen at 7 months of age
|
|
|
• at 2 weeks of age germ cell layers seem to be less organized
|
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|
• at 6 weeks of age
• difference in size is detectable at 2 weeks of age
|
|
|
• seen in older males
|
small testis
(
J:173615
)
|
|
• strikingly smaller at 1 month of age but not at P0 or P5
• difference in size is detectable at 2 weeks of age
|
|
|
• a significant increase in the number of apoptotic oocytes is detected at P0
|
growth/size/body
ovary cyst
(
J:173615
)
|
|
• seen at 7 months of age
|
endocrine/exocrine glands
|
|
• at 7 - 8 weeks of age ovaries contain only a few follicles
• at 7 months of age ovaries are devoid of follicles
|
|
|
• detectable at 3 weeks of age with very few follicles present at 2 months of age
|
small ovary
(
J:173615
)
|
|
• strikingly smaller at 2 months of age
|
ovary cyst
(
J:173615
)
|
|
• seen at 7 months of age
|
|
|
• at 2 weeks of age germ cell layers seem to be less organized
|
|
|
• at 6 weeks of age
• difference in size is detectable at 2 weeks of age
|
|
|
• seen in older males
|
small testis
(
J:173615
)
|
|
• strikingly smaller at 1 month of age but not at P0 or P5
• difference in size is detectable at 2 weeks of age
|
cellular
|
|
• sharp decrease in the number of oocytes detected at birth
|
|
|
• absent at 3 weeks of age
|
|
|
• decreased number of spermatocytes at 2 weeks of age
|
|
|
• decreased number of spermatogonia at 2 weeks of age
|
|
|
• at 6 weeks of age seminiferous tubules are almost completely devoid of germ cells
• in older males the seminiferous tubules are completely devoid of germ cells
|
azoospermia
(
J:173615
)
|
|
• absence of sperm in the epididymal duct lumen at 6 weeks of age
|
|
|
• at 2 weeks of age fewer spermatocytes entering meiosis are detected in the seminiferous tubules
|
|
|
• expression analysis indicates spermatogenesis is arrested around the late pachytene/diplotene stages of meiotic prophase I
|
|
|
• at 3 weeks of age large numbers of apoptotic germ cells are seen
• the few germ cells present at 6 weeks of age are undergoing apoptosis
|
|
|
• at P8 tubules show only sparse and significantly reduced proliferation of spermatogonia
|
