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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptp4a1Gt(CC0606)Wtsi
gene trap CC0606, Wellcome Trust Sanger Institute
MGI:3870365
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi involves: 129P2/OlaHsd * C57BL/6J MGI:6153205
cx2
 		Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi
Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi 		involves: 129P2/OlaHsd * C57BL/6J MGI:6153206
cx3
 		Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi
Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:6153207
cx4
 		Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+
Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi 		involves: 129P2/OlaHsd * C57BL/6J MGI:6153208
cx5
 		Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi
Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Tg(CAG-Ptp4a2,-EGFP)11Zyz/0 		involves: 129P2/OlaHsd * C57BL/6J * FVB/N MGI:6153209
cx6
 		Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+
Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Tg(CAG-Ptp4a2,-EGFP)11Zyz/0 		involves: 129P2/OlaHsd * C57BL/6J * FVB/N MGI:6153210


Genotype
MGI:6153205
hm1
Allelic
Composition		 Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptp4a1Gt(CC0606)Wtsi mutation (0 available); any Ptp4a1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:250112 )
N
• normal organ and cellular morphology as observed through histology
• normal body weight and testis-to-body weight ratio in males

mortality/aging
preweaning lethality, incomplete penetrance ( J:250112 )
• homozygous mice at weaning stage found at a significantly lower rate (143/683) than expected Mendelian ratio (171/683) from heterozygous mutant intercross

reproductive system
reproductive system phenotype ( J:250112 )
N
• Sertoli cell number in 3-months old testis as determined by Vimentin staining
• percentage of proliferating cells and number of apoptotic cells in testis




Genotype
MGI:6153206
cx2
Allelic
Composition		 Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi
Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptp4a1Gt(CC0606)Wtsi mutation (0 available); any Ptp4a1 mutation (15 available)
Ptp4a2Gt(AQ0673)Wtsi mutation (0 available); any Ptp4a2 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:250112 )
• no embryos found at stages E17.5, E14.5, E11.5 or E9.5, no pups found at weaning stage




Genotype
MGI:6153207
cx3
Allelic
Composition		 Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi
Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptp4a1Gt(CC0606)Wtsi mutation (0 available); any Ptp4a1 mutation (15 available)
Ptp4a2Gt(AQ0673)Wtsi mutation (0 available); any Ptp4a2 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:250112 )
N
• Sertoli cell numbers in 3-months old testis as determined by vimentin staining
• numbers of undifferentiated spermatogonia in 3-months old testis as determined by Zbtb16 (PLZF) staining
abnormal male germ cell morphology ( J:250112 )
• some round-shaped non-spermatozoa in cauda epididymis but mostly normal spermatozoa
oligozoospermia ( J:250112 )
• 68 +/- 9% reduction in sperm count in epididymis of 3-months old males compared to wild-type
teratozoospermia ( J:250112 )
• some round-shaped non-spermatozoa in cauda epididymis but mostly normal spermatozoa
• some sperm cells released as a cluster
increased male germ cell apoptosis ( J:250112 )
• 1.6-fold increase in number of apoptotic cells in 3-months old testis according to cleaved-Parp1 staining
abnormal testis morphology ( J:250112 )
• 35 +/- 10% reduction in differentiating spermatogonia and primary spermatocytes as determined by Kit staining
• percentage of proliferating cells as determined by Pcna staining
small seminiferous tubules ( J:250112 )
• diameter reduced by 17 +/- 3%
small testis ( J:250112 )
• reduction in testis weight of 33 +/- 14% compared to wild-type
decreased testis weight ( J:250112 )
• reduction in testis weight of 33 +/- 14% compared to wild-type
• reduction in testis/body weight ratio (normalized body weight) of 19 +/- 12% compared to wild-type
reduced male fertility ( J:250112 )
• significantly reduced pregnancy rates and litter sizes in matings between mutant males and wild-type females compared to wild-type male-female matings

cellular
abnormal male germ cell morphology ( J:250112 )
• some round-shaped non-spermatozoa in cauda epididymis but mostly normal spermatozoa
oligozoospermia ( J:250112 )
• 68 +/- 9% reduction in sperm count in epididymis of 3-months old males compared to wild-type
teratozoospermia ( J:250112 )
• some round-shaped non-spermatozoa in cauda epididymis but mostly normal spermatozoa
• some sperm cells released as a cluster
increased male germ cell apoptosis ( J:250112 )
• 1.6-fold increase in number of apoptotic cells in 3-months old testis according to cleaved-Parp1 staining

endocrine/exocrine glands
abnormal testis morphology ( J:250112 )
• 35 +/- 10% reduction in differentiating spermatogonia and primary spermatocytes as determined by Kit staining
• percentage of proliferating cells as determined by Pcna staining
small seminiferous tubules ( J:250112 )
• diameter reduced by 17 +/- 3%
small testis ( J:250112 )
• reduction in testis weight of 33 +/- 14% compared to wild-type
decreased testis weight ( J:250112 )
• reduction in testis weight of 33 +/- 14% compared to wild-type
• reduction in testis/body weight ratio (normalized body weight) of 19 +/- 12% compared to wild-type

mortality/aging
preweaning lethality, incomplete penetrance ( J:250112 )
• mice at weaning stage found at a significantly lower rate (35/352) than expected Mendelian ratio (44/352) from double heterozygous mutant intercross

growth/size/body
slow postnatal weight gain ( J:250112 )
• reduction in in 4-week old female body weight of 30 +/- 13% compared to wild-type
• reduction in in 4-week old male body weight of 38 +/- 13% compared to wild-type, and 23 +/- 16% compared to single homozygous Ptp4a2 knockout




Genotype
MGI:6153208
cx4
Allelic
Composition		 Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+
Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptp4a1Gt(CC0606)Wtsi mutation (0 available); any Ptp4a1 mutation (15 available)
Ptp4a2Gt(AQ0673)Wtsi mutation (0 available); any Ptp4a2 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:250112 )
N
• Sertoli cell numbers in 3-months old testis as determined by vimentin staining
• numbers of undifferentiated spermatogonia in 3-months old testis as determined by Zbtb16 (PLZF) staining
• mating behavior between mutant males and wild-type females as determined by percentage plugged females
abnormal male germ cell morphology ( J:250112 )
• no normal spermatozoa in cauda epididymis
oligozoospermia ( J:250112 )
• 93 +/- 5% reduction in sperm count in epididymis of 3-months old males compared to wild-type
teratozoospermia ( J:250112 )
• no normal spermatozoa in cauda epididymis
• immature spermatocytes in epididymis
increased male germ cell apoptosis ( J:250112 )
• 6-fold increase in number of apoptotic cells in 3-months old testis according to cleaved-Parp1 staining
• no normal spermatozoa, but instead immature spermatocytes, in epididymis
abnormal testis morphology ( J:250112 )
• percentage of proliferating cells as determined by Pcna staining
• 58 +/- 8% reduction in differentiating spermatogonia and primary spermatocytes as determined by Kit staining
small seminiferous tubules ( J:250112 )
• diameter reduced by 27 +/- 5%
small testis ( J:250112 )
• reduction in testis weight of 59 +/- 16% compared to single homozygous Ptp4a2 knockout (which testes are 43 +/- 8% smaller compared to wild-type)
decreased testis weight ( J:250112 )
• reduction in testis weight of 59 +/- 16% compared to single homozygous Ptp4a2 knockout (which testes are 43 +/- 8% smaller compared to wild-type)
• reduction in testis/body weight ratio (normalized body weight) of 69 +/- 16% compared to wild-type
male infertility ( J:250112 )
• no pups born after mating mutant males with wild-type females

cellular
abnormal male germ cell morphology ( J:250112 )
• no normal spermatozoa in cauda epididymis
oligozoospermia ( J:250112 )
• 93 +/- 5% reduction in sperm count in epididymis of 3-months old males compared to wild-type
teratozoospermia ( J:250112 )
• no normal spermatozoa in cauda epididymis
• immature spermatocytes in epididymis
increased male germ cell apoptosis ( J:250112 )
• 6-fold increase in number of apoptotic cells in 3-months old testis according to cleaved-Parp1 staining
• no normal spermatozoa, but instead immature spermatocytes, in epididymis

endocrine/exocrine glands
abnormal testis morphology ( J:250112 )
• percentage of proliferating cells as determined by Pcna staining
• 58 +/- 8% reduction in differentiating spermatogonia and primary spermatocytes as determined by Kit staining
small seminiferous tubules ( J:250112 )
• diameter reduced by 27 +/- 5%
small testis ( J:250112 )
• reduction in testis weight of 59 +/- 16% compared to single homozygous Ptp4a2 knockout (which testes are 43 +/- 8% smaller compared to wild-type)
decreased testis weight ( J:250112 )
• reduction in testis weight of 59 +/- 16% compared to single homozygous Ptp4a2 knockout (which testes are 43 +/- 8% smaller compared to wild-type)
• reduction in testis/body weight ratio (normalized body weight) of 69 +/- 16% compared to wild-type

mortality/aging
preweaning lethality, incomplete penetrance ( J:250112 )
• mice at weaning stage found at a significantly lower rate (27/352) than expected Mendelian ratio (44/352) from double heterozygous mutant intercross

growth/size/body
slow postnatal weight gain ( J:250112 )
• reduction in in 4-week old male body weight of 41+/- 10% compared to wild-type, and 27 +/- 12% compared to single homozygous Ptp4a2 knockout
• reduction in in 4-week old female body weight of 26 +/- 14% compared to wild-type




Genotype
MGI:6153209
cx5
Allelic
Composition		 Ptp4a1Gt(CC0606)Wtsi/Ptp4a1Gt(CC0606)Wtsi
Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2+
Tg(CAG-Ptp4a2,-EGFP)11Zyz/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptp4a1Gt(CC0606)Wtsi mutation (0 available); any Ptp4a1 mutation (15 available)
Ptp4a2Gt(AQ0673)Wtsi mutation (0 available); any Ptp4a2 mutation (76 available)
Tg(CAG-Ptp4a2,-EGFP)11Zyz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:250112 )
N
• body weight and testis-to-body weight ratio

mortality/aging

reproductive system
reproductive system phenotype ( J:250112 )
N
• fertile
• testis size, weight and morphology




Genotype
MGI:6153210
cx6
Allelic
Composition		 Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+
Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Tg(CAG-Ptp4a2,-EGFP)11Zyz/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptp4a1Gt(CC0606)Wtsi mutation (0 available); any Ptp4a1 mutation (15 available)
Ptp4a2Gt(AQ0673)Wtsi mutation (0 available); any Ptp4a2 mutation (76 available)
Tg(CAG-Ptp4a2,-EGFP)11Zyz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:250112 )
N
• body weight and testis-to-body weight ratio

mortality/aging

reproductive system
reproductive system phenotype ( J:250112 )
N
• fertile
• testis size, weight and morphology




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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory