Phenotypes associated with this allele

• Allele Symbol: Cep131^{Gt(CC0635)Wtsi}
• Allele Name: gene trap CC0635, Wellcome Trust Sanger Institute
• Allele ID: MGI:3870375
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cep131^Gt(CC0635)Wtsi/Cep131^Gt(CC0635)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5699361

Genotype
MGI:5699361

hm1

• Allelic Composition: Cep131^{Gt(CC0635)Wtsi}/Cep131^{Gt(CC0635)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:223125 )

• only about 2/3 of expected homozygotes present at weaning

• a significant reduction of homozygotes by around E11.5-E13.5

growth/size/body

growth/size/body region phenotype ( J:223125 )

N • pups appear normal at birth

N • body weight at birth is normal

cellular

cellular phenotype ( J:223125 )

N • no gross abnormalities associated with cell cilia or cilia function

N • centriolar satellite formation normal in cultured MEFs

N • centrosome and centriole numbers normal

N • chromosome stability appears normal

oligozoospermia ( J:223125 )

♂ • drastically reduced sperm density in testes (less than 2% of wild type)

teratozoospermia ( J:223125 )

♂ • manchette of sperm kinked and often mis-positioned

abnormal sperm flagellum morphology ( J:223125 )

♂ • sperm flagella are shorter and morphologically abnormal

♂ • drastically reduced sperm flagella in seminiferous tubules

abnormal sperm axoneme morphology ( J:223125 )

♂

abnormal sperm connecting piece morphology ( J:223125 )

♂ • head-tail coupling apparatus often misaligned

short sperm flagellum ( J:223125 )

♂

detached acrosome ( J:223125 )

♂

abnormal sperm nucleus morphology ( J:223125 )

♂ • sperm heads show an abnormal club-shaped nuclear morphology

increased male germ cell apoptosis ( J:223125 )

♂ • spermatids start entering into apoptosis in step 9

reproductive system

increased male germ cell apoptosis ( J:223125 )

♂ • spermatids start entering into apoptosis in step 9

abnormal testis morphology ( J:223125 )

♂

small seminiferous tubules ( J:223125 )

♂ • significant reductions in tubule lumen diameter

decreased testis weight ( J:223125 )

♂

abnormal gametogenesis ( J:223125 )

♂

abnormal spermatogenesis ( J:223125 )

♂

oligozoospermia ( J:223125 )

♂ • drastically reduced sperm density in testes (less than 2% of wild type)

teratozoospermia ( J:223125 )

♂ • manchette of sperm kinked and often mis-positioned

abnormal sperm flagellum morphology ( J:223125 )

♂ • sperm flagella are shorter and morphologically abnormal

♂ • drastically reduced sperm flagella in seminiferous tubules

abnormal sperm axoneme morphology ( J:223125 )

♂

abnormal sperm connecting piece morphology ( J:223125 )

♂ • head-tail coupling apparatus often misaligned

short sperm flagellum ( J:223125 )

♂

detached acrosome ( J:223125 )

♂

abnormal sperm nucleus morphology ( J:223125 )

♂ • sperm heads show an abnormal club-shaped nuclear morphology

abnormal spermiogenesis ( J:223125 )

♂ • normal up to steps 7-8

♂ • step 9 spermatid morphology is highly abnormal, with elongating spermatids mis-localized and mis-oriented within the tubules

♂ • spermatids start entering into apoptosis in step 9

abnormal epididymis morphology ( J:223125 )

♂ • Cauda or caput epididymides contain only debris and degenerating sperm

male infertility ( J:223125 )

♂ • males are completely infertile whereas female fertility is normal

respiratory system

respiratory system phenotype ( J:223125 )

N • cilia of airway epithelia are normal

vision/eye

vision/eye phenotype ( J:223125 )

N • no sign of retinal degeneration in aged mice

renal/urinary system

renal/urinary system phenotype ( J:223125 )

N • no kidney cysts

endocrine/exocrine glands

abnormal testis morphology ( J:223125 )

♂

small seminiferous tubules ( J:223125 )

♂ • significant reductions in tubule lumen diameter

decreased testis weight ( J:223125 )

♂